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The PASS\u2010ALL study is a multicentre, observational cohort study, and 143 patients with HR B\u2010cell PH\u2010ve ALL were enrolled from five centres\u201477 patients allocated in the paediatric\u2010inspired cohort and 66 in the adult cohort with comparable baseline characteristics. Of the 143 patients, 128 cases underwent allo\u2010HSCT. Three\u2010year leukaemia\u2010free survival (LFS) in the paediatric\u2010inspired cohort was 72.2% (95% CI 60.8%\u201383.6%) compared with 44.6% (95% CI 31.9%\u201357.3%; <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Furthermore, time\u2010to\u2010positive minimal residual disease (TTP\u2010MRD) post\u2010HSCT was marked different, 3\u2010year cumulative incidence of relapse was 25.9% (95% CI 15.8%\u201337.2%) in paediatric cohort and 45.4% (95% CI 40.0%\u201357.9%) in adult cohort (<jats:italic>p<\/jats:italic>\u2009=\u20090.026). Finally, the 3\u2010year OS rate was 75.3% (95% CI 64.9%\u201385.7%) for the paediatric\u2010inspired cohort and 64.1% (95% CI 51.8%\u201376.4%) for the adult cohort (<jats:italic>p<\/jats:italic>\u2009=\u20090.074). On a multivariate analysis, paediatric\u2010inspired regimen is a predictive factor for LFS (HR\u2009=\u20092.540, 95% CI 1.327\u20134.862, <jats:italic>p<\/jats:italic>\u2009=\u20090.005). Collectively, our data suggest that paediatric\u2010inspired chemotherapy pre\u2010HSCT results in deeper and durable MRD response reduces relapse post\u2010HSCT and improves survival in HR B\u2010cell PH\u2010ve ALL patients with allo\u2010HSCT.<\/jats:p>","DOI":"10.1111\/bjh.19223","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T08:08:41Z","timestamp":1701763721000},"page":"628-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["PASS\u2010ALL study of paediatric\u2010inspired versus adult chemotherapy regimens on survival of high\u2010risk Philadelphia\u2010negative B\u2010cell acute lymphoblastic leukaemia with allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9091-2673","authenticated-orcid":false,"given":"Zhixiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department 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