{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:33:16Z","timestamp":1773797596356,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/4yPhD\/F\/21\/34162"],"award-info":[{"award-number":["FS\/4yPhD\/F\/21\/34162"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009032","name":"Pfizer UK","doi-asserted-by":"publisher","award":["WI255886"],"award-info":[{"award-number":["WI255886"]}],"id":[{"id":"10.13039\/100009032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Despite significant global morbidity associated with respiratory infection, there is a paucity of data examining the association between severity of non\u2010SARS\u2010CoV\u20102 respiratory infection and blood group. We analysed a prospective cohort of adults hospitalised in Bristol, UK, from 1 August 2020 to 31 July 2022, including patients with acute respiratory infection (pneumonia [\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091934] and non\u2010pneumonic lower respiratory tract infection [NP\u2010LRTI] [\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091184]), a negative SARS\u2010CoV\u20102 test and known blood group status. The likelihood of cardiovascular complication, survival and hospital admission length was assessed using regression models with group O and RhD\u2010negative status as reference groups. Group A and RhD\u2010positive were over\u2010represented in both pneumonia and NP\u2010LRTI compared to a first\u2010time donor population (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 in all); contrastingly, group O was under\u2010represented. ABO group did not influence cardiovascular complication risk; however, RhD\u2010positive patients with pneumonia had a reduced odds ratio (OR) for cardiovascular complications (OR\u2009=\u20090.77 [95% CI\u2009=\u20090.59\u20130.98]). Compared to group O, group A individuals with NP\u2010LRTI were more likely to be discharged within 60\u2009days (hazard ratio [HR]\u2009=\u20091.17 [95% CI\u2009=\u20091.03\u20131.33]), while group B with pneumonia was less likely (HR\u2009=\u20090.8 [95% CI\u2009=\u20090.66\u20130.96]). This analysis provides some evidence that blood group status may influence clinical outcome following respiratory infection, with group A having increased risk of hospitalisation and RhD\u2010positive patients having reduced cardiovascular complications.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19234","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T18:37:57Z","timestamp":1701110277000},"page":"826-838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of\n                    <scp>ABO<\/scp>\n                    and Rhesus blood groups with severe outcomes from\n                    <scp>non\u2010SARS\u2010CoV<\/scp>\n                    \u20102 respiratory infection: A prospective observational cohort study in Bristol,\n                    <scp>UK<\/scp>\n                    2020\u20132022"],"prefix":"10.1111","volume":"204","author":[{"given":"Alice","family":"Hathaway","sequence":"first","affiliation":[{"name":"School of Biochemistry University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Qian","sequence":"additional","affiliation":[{"name":"Engineering Mathematics University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade","family":"King","sequence":"additional","affiliation":[{"name":"Clinical Research and Imaging Centre UHBW NHS Trust  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"McGuinness","sequence":"additional","affiliation":[{"name":"Bristol Vaccine Centre and Population Health Sciences University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Maskell","sequence":"additional","affiliation":[{"name":"Academic Respiratory Unit University of Bristol, Southmead Hospital  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Oliver","sequence":"additional","affiliation":[{"name":"Bristol Vaccine Centre and Population Health Sciences University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Finn","sequence":"additional","affiliation":[{"name":"Bristol Vaccine Centre, Cellular and Molecular Medicine and Population Health Sciences University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Danon","sequence":"additional","affiliation":[{"name":"Engineering Mathematics University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Challen","sequence":"additional","affiliation":[{"name":"Engineering Mathematics University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4395-9396","authenticated-orcid":false,"given":"Ashley M.","family":"Toye","sequence":"additional","affiliation":[{"name":"School of Biochemistry University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3923-1773","authenticated-orcid":false,"given":"Catherine","family":"Hyams","sequence":"additional","affiliation":[{"name":"Bristol Vaccine Centre, Cellular and Molecular Medicine and Population Health Sciences University of Bristol  Bristol UK"},{"name":"Academic Respiratory Unit and Bristol Vaccine Centre University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Avon CAP Research Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00510-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08119.x"},{"key":"e_1_2_10_4_1","unstructured":"National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health.Advances in knowledge of the health consequences of smoking: from 1964\u20132014.The health consequences of smoking\u201450\u2009years of progress: a report of the Surgeon General[Centers for Disease Control and Prevention (US)] 2014."},{"key":"e_1_2_10_5_1","unstructured":"AleemMS SextonR AkellaJ.Pneumonia in an immunocompromised patient. 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