{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:50:27Z","timestamp":1789498227186,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>First\u2010line purine nucleoside analogues (PNAs) in hairy cell leukaemia (HCL) allow deep and long\u2010lasting responses. We retrospectively analysed 53 HCL patients treated frontline with cladribine and assessed for response at 2 and 6\u2009months after treatment to evaluate the kinetics of response. The estimated median progression\u2010free survival was significantly different according to the degree of residual HCL infiltrate detected by immunohistochemistry at the bone marrow biopsy at 2\u2009months (\u22645% vs. &gt;5%, 247 vs. 132\u2009months, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.033), but not at 6\u2009months (<jats:italic>p<\/jats:italic>\u2009=\u20090.79). Our data suggest a favourable prognostic impact of early marrow HCL clearance in patients treated with cladribine.<\/jats:p>","DOI":"10.1111\/bjh.19237","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T07:48:50Z","timestamp":1701762530000},"page":"1288-1292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early clearance of hairy cell leukaemia in the bone marrow after first\u2010line treatment with cladribine predicts a favourable outcome"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2803-3766","authenticated-orcid":false,"given":"S.","family":"Ligia","sequence":"first","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-2218","authenticated-orcid":false,"given":"M.","family":"Passucci","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-9635","authenticated-orcid":false,"given":"G. 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