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This emphasises the need for advanced models for preclinical evaluation of new therapeutic approaches for bortezomib\u2010resistant MM. Here, we describe the development of an orthotopic syngeneic bortezomib\u2010resistant MM mouse model based on the most well\u2010characterised syngeneic MM mouse model derived from spontaneous MM\u2010forming C57BL\/KaLwRij mice. Using bortezomib\u2010resistant 5TGM1 cells, we report and characterise a robust syngeneic mouse model of bortezomib\u2010resistant MM that is well suited to the evaluation of new therapeutic approaches for proteasome inhibitor\u2010resistant MM.<\/jats:p>","DOI":"10.1111\/bjh.19240","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T05:20:17Z","timestamp":1701840017000},"page":"566-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An orthotopic syngeneic mouse model of bortezomib\u2010resistant multiple myeloma"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5296-7614","authenticated-orcid":false,"given":"Manjun","family":"Li","sequence":"first","affiliation":[{"name":"Centre for Cancer Biology University of South Australia and SA Pathology  Adelaide South Australia 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