{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:17:35Z","timestamp":1788999455772,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy and bispecific T\u2010cell engagers (BsAb) have emerged as promising immunotherapeutic modalities in patients with relapsed and\/or refractory multiple myeloma (RRMM). However, there is limited data on the safety and efficacy of CAR\u2010T and BsAb therapies in MM patients with a prior history of allogeneic transplantation (allo\u2010HCT). Thirty\u2010three MM patients with prior allo\u2010HCT received CAR\u2010T (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924) or BsAb (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099) therapy. CAR\u2010T therapy demonstrated an ORR of 92% (67%\u2009\u2265\u2009CR), and 73% were MRD negative. BsAb therapy resulted in an ORR of 44% (44%\u2009\u2265\u2009CR) and 44% MRD negative. Safety analysis showed grade \u22653 AEs in 92% of CAR\u2010T and 56% of BsAb patients. Cytokine release syndrome (CRS) occurred in 83% of CAR\u2010T and 78% of BsAb recipients, while immune effector cell\u2010associated neurotoxicity syndrome (ICANS) was observed in three CAR\u2010T patients. Infections of grade \u22653 were reported in 50% of CAR\u2010T and 44% of BsAb recipients. No exacerbation of graft\u2010versus\u2010host disease occurred except in one BsAb recipient. CAR\u2010T and BsAb therapies appear to be feasible, safe and provide deep and durable responses in MM patients with prior allo\u2010HCT.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19244","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T12:33:34Z","timestamp":1701866014000},"page":"887-891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Chimeric antigen receptor and bispecific T\u2010cell engager therapies in multiple myeloma patients with prior allogeneic transplantation"],"prefix":"10.1111","volume":"204","author":[{"given":"Lindsay","family":"Hammons","sequence":"first","affiliation":[{"name":"BMT and Cellular Therapy Program, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabi","family":"Haider","sequence":"additional","affiliation":[{"name":"BMT and Cellular Therapy Program, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-4578","authenticated-orcid":false,"given":"Andrew J.","family":"Portuguese","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-5441","authenticated-orcid":false,"given":"Rahul","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniko","family":"Szabo","sequence":"additional","affiliation":[{"name":"BMT and Cellular Therapy Program, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1579-2293","authenticated-orcid":false,"given":"Marcelo","family":"Pasquini","sequence":"additional","affiliation":[{"name":"BMT and Cellular Therapy Program, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9117-8696","authenticated-orcid":false,"given":"Saurabh","family":"Chhabra","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine Mayo Clinic Arizona  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabarinath","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"BMT and Cellular Therapy Program, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6913-6526","authenticated-orcid":false,"given":"Meera","family":"Mohan","sequence":"additional","affiliation":[{"name":"BMT and Cellular Therapy Program, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Narra","sequence":"additional","affiliation":[{"name":"BMT and Cellular Therapy Program, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Dong","sequence":"additional","affiliation":[{"name":"BMT and Cellular Therapy Program, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Janz","sequence":"additional","affiliation":[{"name":"BMT and Cellular Therapy Program, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4336-1071","authenticated-orcid":false,"given":"Nirav N.","family":"Shah","sequence":"additional","affiliation":[{"name":"BMT and Cellular Therapy Program, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5372-510X","authenticated-orcid":false,"given":"Mehdi","family":"Hamadani","sequence":"additional","affiliation":[{"name":"BMT and Cellular Therapy Program, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-5643","authenticated-orcid":false,"given":"Anita","family":"D'Souza","sequence":"additional","affiliation":[{"name":"BMT and Cellular Therapy Program, Department 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