{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:33:32Z","timestamp":1778186012381,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Immune\u2010mediated thrombotic thrombocytopenic purpura (iTTP) is a rare condition caused by severe ADAMTS13 deficiency, leading to platelet aggregation and thrombosis. Despite treatment, patients are prone to cognitive impairment and depression. We investigated brain changes in iTTP patients during remission using advanced magnetic resonance imaging (MRI) techniques, correlating these changes with mood and neurocognitive tests. Twenty iTTP patients in remission (30\u2009days post\u2010haematological remission) were compared with six healthy controls. MRI scans, including standard and specialized sequences, were conducted to assess white matter health. Increased T1 relaxation times were found in the cingulate cortex (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), and elevated T2 relaxation times were observed in the cingulate cortex, frontal, parietal and temporal lobes (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Pathological changes in these areas are correlated with impaired cognitive and depressive scores in concentration, short\u2010term memory and verbal memory. This study highlights persistent white matter damage in iTTP patients, potentially contributing to depression and cognitive impairment. Key regions affected include the frontal lobe and cingulate cortex. These findings have significant implications for the acute and long\u2010term management of iTTP, suggesting a need for re\u2010evaluation of treatment approaches during both active phases and remission. Further research is warranted to enhance our understanding of these complexities.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19246","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T15:26:48Z","timestamp":1702394808000},"page":"1005-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cognitive decline in thrombotic thrombocytopenic purpura survivors: The role of white matter health as assessed by\n                    <scp>MRI<\/scp>"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8321-683X","authenticated-orcid":false,"given":"F.","family":"Hannan","sequence":"first","affiliation":[{"name":"Department of Medical Biophysics Western University  London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics Western University  London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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