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We identified 14 patients with <jats:italic>FLT3<\/jats:italic>\u2010 or <jats:italic>IDH<\/jats:italic><jats:italic>1\/2<\/jats:italic>\u2010mutated ALL. Three early T\u2010cell precursor\u2010ALL patients received FLT3 or IDH2 inhibitors. Patient 1 maintains a complete remission (CR) with enasidenib after intolerance to chemotherapy. Patient 2 maintained a CR for 27\u2009months after treatment with enasidenib for relapsed disease. Patient 3 was treated with venetoclax and gilteritinib at the time of relapse and maintained a CR with gilteritinib for 8\u2009months. These cases suggest that FLT3 and IDH inhibitors could represent a viable therapeutic option for ALL patients with these mutations.<\/jats:p>","DOI":"10.1111\/bjh.19250","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T05:58:37Z","timestamp":1702274317000},"page":"1238-1242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Durable responses in acute lymphoblastic leukaemia with the use of <scp>FLT3<\/scp> and <scp>IDH<\/scp> inhibitors"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9243-2662","authenticated-orcid":false,"given":"Rafael","family":"Madero\u2010Marroquin","sequence":"first","affiliation":[{"name":"Section of Hematology\/Oncology, Department of Medicine University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam 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