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Pathological outcomes of ID include delayed cognitive development in children, adverse pregnancy outcomes and decreased work capacity in adults. IDA is usually treated by oral iron supplementation, typically using iron salts (e.g. FeSO\n                    <jats:sub>4<\/jats:sub>\n                    ); however, dosing at several\u2010fold above the RDA may be required due to less efficient absorption. Excess enteral iron causes adverse gastrointestinal side effects, thus reducing compliance, and negatively impacts the gut microbiome. Recent research has sought to identify new iron formulations with better absorption so that lower effective dosing can be utilized. This article outlines emerging research on oral iron supplementation and focuses on molecular mechanisms by which different supplemental forms of iron are transported across the intestinal epithelium and whether these transport pathways are subject to regulation by the iron\u2010regulatory hormone hepcidin.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19268","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T21:46:07Z","timestamp":1705959967000},"page":"759-773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2879-0475","authenticated-orcid":false,"given":"Pearl O.","family":"Ebea\u2010Ugwuanyi","sequence":"first","affiliation":[{"name":"Food Science &amp; Human Nutrition Department University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadasivan","family":"Vidyasagar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Connor","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Frazer","sequence":"additional","affiliation":[{"name":"Molecular Nutrition Laboratory QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell D.","family":"Knutson","sequence":"additional","affiliation":[{"name":"Food Science &amp; Human Nutrition Department University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8765-0297","authenticated-orcid":false,"given":"James F.","family":"Collins","sequence":"additional","affiliation":[{"name":"Food Science &amp; Human Nutrition Department University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"CDC.Micronutrient facts|nutrition|CDC: @CDCgov.2022[updated 2022 Feb 1 T06:31:52Z]. 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