{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:38:15Z","timestamp":1773250695833,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T00:00:00Z","timestamp":1705795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T00:00:00Z","timestamp":1705795200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The presence of transient abnormal protein banding (M\u2010protein immune reconstitution) in serum immunofixation electrophoresis after autologous haematopoietic stem cell transplantation in patients with multiple myeloma has been reported. The purpose of this study was to investigate the impact of post\u2010transplant M\u2010protein immune reconstitution on the prognosis of patients with multiple myeloma. M\u2010protein immune reconstitution was observed in 25.9% (75\/290) of patients. The CR rate and MRD negativity were higher in the M\u2010protein immune reconstitution group (85.3% vs. 69.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.013, 81.9% vs. 66.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014). Although there were no significant differences between the groups, the overall median survival time was longer in the M\u2010protein immune reconstruction group (80 vs. 72\u2009m,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.076; not reached vs. 105\u2009m,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.312). Among patients in the cytogenetic high\u2010risk group, the occurrence of M\u2010protein immune reconstitution predicted better PFS and OS (80 vs. 31\u2009m,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010; not reached vs. 91\u2009m,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026). Additionally, in revised\u2010International Staging System stage III patients, PFS and OS were better in those who achieved M\u2010protein immune reconstitution (80 vs. 20\u2009m,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.025; 57 vs. 32\u2009m,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.103). The better prognosis of M\u2010protein immune reconstitution patients may be associated with the acquisition of a deeper response. In high\u2010risk patients, early acquisition of M\u2010protein immune reconstitution may suggest a better prognosis.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19275","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T22:29:46Z","timestamp":1705876186000},"page":"976-987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Early M\u2010protein immune reconstitution after autologous haematopoietic stem cell transplantation is a good prognostic marker for patients with high\u2010risk cytogenetic multiple myeloma"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5876-9192","authenticated-orcid":false,"given":"Huihui","family":"Zhu","sequence":"first","affiliation":[{"name":"Haematology Sun Yat\u2010sen University First Affiliated Hospital  Guangzhou Guangdong 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