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In this work we explored the prognostic impact of cell\u2010free DNA (cfDNA) concentration in 75 newly diagnosed patients enrolled in a prospective multicenter study. Pre\u2010treatment cfDNA was strongly associated with clinical risk factors and was identified as a superior predictor for shorter progression\u2010free survival in multivariable analysis, outweighing canonical risk parameters. Furthermore, we identified a cfDNA value above which survival worsens. In conclusion, pre\u2010treatment cfDNA concentration represents an easily usable predictive biomarker that is highly associated with survival of PTCL patients.<\/jats:p>","DOI":"10.1111\/bjh.19280","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T23:29:26Z","timestamp":1704410966000},"page":"1752-1756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic impact of pretreatment cell\u2010free <scp>DNA<\/scp> concentration in newly diagnosed peripheral T\u2010cell lymphomas"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0273-1316","authenticated-orcid":false,"given":"E.","family":"Fardella","sequence":"first","affiliation":[{"name":"University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Zanirato","sequence":"additional","affiliation":[{"name":"Division of Hematology and Stem Cell Transplantation Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Magni","sequence":"additional","affiliation":[{"name":"Division of Hematology and Stem Cell Transplantation Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Caldarelli","sequence":"additional","affiliation":[{"name":"University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2977-0098","authenticated-orcid":false,"given":"A.","family":"Chiappella","sequence":"additional","affiliation":[{"name":"Division of Hematology and Stem Cell Transplantation Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dodero","sequence":"additional","affiliation":[{"name":"Division of Hematology and Stem Cell Transplantation Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ljevar","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics for Clinical Research Fondazione IRCCS Istituto Nazionale dei Tumori  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Orsucci","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Ospedaliera e Universitaria Citt\u00e0 della Salute e della Scienza  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Re","sequence":"additional","affiliation":[{"name":"Hematology Division ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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