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Few studies have compared the efficacy and safety of the HSCT donor and third\u2010party CMV\u2010specific cytotoxic T lymphocytes (CMV\u2010CTLs) in the treatment of CMV DNAemia and disease. In this study, we retrospectively compared the efficacy and safety of HSCT donor and third\u2010party CMV\u2010CTLs in patients with refractory CMV DNAemia or disease after allo\u2010HSCT at our centre from January 2017 to September 2021. Fifty\u2010three patients who received CMV\u2010CTL therapy were enrolled, including 40 in the donor group and 13 in the third\u2010party group, and they were adults aged 18\u2009years or older. Within 6\u2009weeks of treatment, 26 (65.0%) and 9 (69.2%) patients achieved complete response in the donor and third\u2010party groups (<jats:italic>p<\/jats:italic>\u2009=\u20091.000). The 2\u2010year overall survival was 59.6% (95% CI 46.1%\u201377.1%) and 53.8% (32.6%\u201389.1%) in the donor and third\u2010party groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.860). Four (10.0%) patients in the donor group and two (15.4%) patients in the third\u2010party group developed acute graft\u2010versus\u2010host disease within 3\u2009months after CMV\u2010CTL infusions. In conclusion, our data suggest that donor and third\u2010party CMV\u2010CTLs have comparable efficacy and safety for refractory CMV DNAemia and disease.<\/jats:p>","DOI":"10.1111\/bjh.19282","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:18:05Z","timestamp":1704241085000},"page":"1393-1401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Adoptive therapy with cytomegalovirus\u2010specific cytotoxic T lymphocytes for refractory cytomegalovirus <scp>DNAemia<\/scp> and disease after allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"204","author":[{"given":"Zhonghui","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Hematology Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"Clinical Medical Research Center of Hematology Diseases of Guangdong Province  Guangzhou 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