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Disease progression in the first year post\u2010QUADs is uncommon. We analysed 274 consecutive NDMM patients treated with QUADs\u2009+\u2009ASCT. After a median follow\u2010up of 21.3 months, 20 patients had disease progression &lt;18\u2009months and 21 had progression \u226518\u2009months after the onset of a QUAD regimen. All patients received subsequent anti\u2010MM therapy, and 38 were evaluated for response. Nine (22.0%) received T\u2010cell redirecting therapy as the next treatment, and 21 (51.2%) at some point in the treatment course. Response to next therapy was 26.3% for patients with progression &lt;18\u2009months and 52.6% for those with progression \u226518\u2009months after the onset of a QUAD regimen. Median PFS on the next therapy was 2.5\u2009months (95% CI 1.5\u20133.4) for those with progression &lt;18\u2009months and 7.0 months (95% CI 3.6\u201310.5) for those with progression \u226518\u2009months. Efforts should focus on the early deployment of therapies with new mechanism of action for patients experiencing treatment failure after QUADs.<\/jats:p>","DOI":"10.1111\/bjh.19303","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T05:59:10Z","timestamp":1706680750000},"page":"1300-1306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Subsequent therapy and outcomes in patients with newly diagnosed multiple myeloma experiencing disease progression after quadruplet combinations"],"prefix":"10.1111","volume":"204","author":[{"given":"Gayathri","family":"Ravi","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Bal","sequence":"additional","affiliation":[{"name":"Division of Hematology and 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