{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:56:06Z","timestamp":1784832966906,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007311","name":"Deutsche Kinderkrebsstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007311","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Frequency, distribution and prognostic meaning of <jats:italic>ALK<\/jats:italic>\u2010partner genes other than <jats:italic>NPM1<\/jats:italic> in ALK\u2010positive anaplastic large\u2010cell lymphoma (ALCL) are unknown. Forty\u2010nine of 316 ALCL diagnosed in the NHL\u2010BFM study group showed no nuclear ALK expression suggestive of a variant <jats:italic>ALK<\/jats:italic>\u2010partner; 41 were analysed by genomic capture high\u2010throughput sequencing or specific RT\u2010PCRs. <jats:italic>NPM1::ALK<\/jats:italic> was detected in 13 cases. Among the 28 patients with a non\u2010<jats:italic>NPM1::ALK<\/jats:italic>\u2010fusion partner, <jats:italic>ATIC<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20098; 29%) and <jats:italic>TPM3<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20099; 32%) were the most common. Five of eight patients with <jats:italic>ATIC::ALK<\/jats:italic>\u2010positive ALCL relapsed, none of nine with <jats:italic>TPM3::ALK.<\/jats:italic> Variant ALK\u2010partners are rare and potentially associated with different prognoses.<\/jats:p>","DOI":"10.1111\/bjh.19308","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T07:35:11Z","timestamp":1706340911000},"page":"1894-1898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Variant <scp>ALK<\/scp>\u2010fusion positive anaplastic large cell lymphoma (<scp>ALCL<\/scp>): A population\u2010based paediatric study of the <scp>NHL\u2010BFM<\/scp> study group"],"prefix":"10.1111","volume":"204","author":[{"given":"Jette","family":"Luedersen","sequence":"first","affiliation":[{"name":"Paediatric Haematology and Oncology and NHL\u2010BFM Study Centre University Medical Centre Hamburg\u2010Eppendorf  Hamburg 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