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The dysregulation of the hepcidin axis was observed by Latour et\u00a0al. in a mouse model of malarial anaemia induced by prolonged <jats:italic>Plasmodium<\/jats:italic> infection leading to increased erythroferrone concentrations. In line with that, we found significantly higher erythroferrone levels in cases with malaria and anaemia in an African population, compared to asymptomatic controls. Therefore, our findings extend the previous ones of the mouse model, suggesting also a dysregulation of the hepcidin axis in humans, which should be further corroborated in prospective studies and may lay the basis for the development of improved treatment strategies according to ERFE concentrations in such patients.<\/jats:p>","DOI":"10.1111\/bjh.19309","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T06:54:51Z","timestamp":1706338491000},"page":"2066-2070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased erythroferrone levels in malarial anaemia"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8682-9578","authenticated-orcid":false,"given":"Peter J.","family":"Neyer","sequence":"first","affiliation":[{"name":"Institute of Laboratory Medicine Cantonal Hospital Aarau  Aarau Switzerland"},{"name":"Graduate School for Cellular &amp; 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