{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:41:09Z","timestamp":1773114069730,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","award":["CA021765"],"award-info":[{"award-number":["CA021765"]}],"id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","award":["CA023944"],"award-info":[{"award-number":["CA023944"]}],"id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Children with acute lymphoblastic leukaemia (ALL) are at risk for obesity and cardiometabolic diseases. To gain insight into body composition changes among children with ALL, we assessed quantitative computed tomography (QCT) data for specific body compartments (subcutaneous adipose tissue [SAT], visceral adipose tissue [VAT], total adipose tissue [TAT], lean tissue [LT], LT\/TAT and VAT\/SAT at lumbar vertebrae L1 and L2) at diagnosis and at off\u2010therapy for 189 children with ALL and evaluated associations between body mass index (BMI) <jats:italic>Z<\/jats:italic>\u2010score and clinical characteristics. BMI <jats:italic>Z<\/jats:italic>\u2010score correlated positively with SAT, VAT and TAT and negatively with LT\/TAT and VAT\/SAT. At off\u2010therapy, BMI <jats:italic>Z<\/jats:italic>\u2010score, SAT, VAT and TAT values were higher than at diagnosis, but LT, LT\/TAT and VAT\/SAT were lower. Patients aged \u226510\u2009years at diagnosis had higher SAT, VAT and TAT and lower LT and LT\/TAT than patients aged 2.0\u20139.9\u2009years. Female patients had lower LT and LT\/TAT than male patients. Black patients had less VAT than White patients. QCT analysis showed increases in adipose tissue and decreases in LT during ALL therapy when BMI <jats:italic>Z<\/jats:italic>\u2010scores increased. Early dietary and physical therapy interventions should be considered, particularly for patients at risk for obesity.<\/jats:p>","DOI":"10.1111\/bjh.19310","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T06:05:02Z","timestamp":1706681102000},"page":"1335-1343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantitative computed tomography analysis of body composition changes in paediatric patients with acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7517-1416","authenticated-orcid":false,"given":"Kunanya","family":"Suwannaying","sequence":"first","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Pediatrics Khon Kaen University  Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian A.","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikeenkumar","family":"Dhaduk","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deqing","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Merkle","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Pediatrics University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony Z.","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea G.","family":"Goodenough","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joren","family":"Brown","sequence":"additional","affiliation":[{"name":"Mindways Software, Inc  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily K.","family":"Browne","sequence":"additional","affiliation":[{"name":"Department of Psychosocial Services St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Wolcott","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen L.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Hon","family":"Pui","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Pediatrics University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten K.","family":"Ness","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue C.","family":"Kaste","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Diagnostic Imaging St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Radiology University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0605-7342","authenticated-orcid":false,"given":"Hiroto","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Pediatrics University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0136-6"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30031-2"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12754"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.732"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31736"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3332"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81507"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05488"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20689"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20205"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/38447238"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.95"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900386"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.1.45"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-018-0122-1"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/378632"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jicru_os23.1.20"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29337"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1139\/H08-075"},{"key":"e_1_2_13_21_1","volume-title":"Statistics without maths for psychology","author":"Dancey CP","year":"2007"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803780"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17716-0"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140711"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.03.06.dc05-1500"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30050-X"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1136741"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2639-5"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20150507"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020004018"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-595389"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13892"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2016.0023"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T15:37:30Z","timestamp":1712763450000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,30]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/bjh.19310"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19310","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,30]]},"assertion":[{"value":"2023-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}