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TELESTO (NCT00940602) was a prospective, placebo\u2010controlled, randomised study to evaluate the iron chelator deferasirox in patients with low\u2010 or intermediate\u20101\u2013risk MDS and iron overload. Echocardiographic parameters were collected at screening and during treatment. Patients receiving deferasirox experienced a significant decrease in the composite risk of hospitalisation for congestive heart failure (CHF) or worsening of cardiac function (HR\u2009=\u20090.23; 95% CI: 0.05, 0.99; nominal <jats:italic>p<\/jats:italic>\u2009=\u20090.0322) versus placebo. No significant differences between the arms were found in left ventricular ejection fraction, ventricular diameter and mass or pulmonary artery pressure. The absolute number of events was low, but the enrolled patients were younger than average for patients with MDS, with no serious cardiac comorbidities and a modest cardiovascular risk profile. These results support the effectiveness of deferasirox in preventing cardiac damage caused by iron overload in this patient population. Identification of patients developing CHF is challenging due to the lack of distinctive echocardiographic features. The treatment of iron overload may be important to prevent cardiac dysfunction in these patients, even those with moderate CHF risk.<\/jats:p>","DOI":"10.1111\/bjh.19316","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T05:50:13Z","timestamp":1707717013000},"page":"2049-2056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiac effects of deferasirox in transfusion\u2010dependent patients with myelodysplastic syndromes: <scp>TELESTO<\/scp> study"],"prefix":"10.1111","volume":"204","author":[{"given":"Matteo","family":"Sarocchi","sequence":"first","affiliation":[{"name":"Cardiovascular Disease Unit IRCCS Ospedale Policlinico San Martino  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0775-0878","authenticated-orcid":false,"given":"Junmin","family":"Li","sequence":"additional","affiliation":[{"name":"School of 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