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We enrolled and dewormed 24 iron\u2010depleted Kenyan children, 24\u201327\u2009months of age, whose body iron was enriched and equilibrated with <jats:sup>58<\/jats:sup>Fe given at least 1\u2009year earlier. Over 3\u2009months of supplementation (6\u2009mg iron\/kg body weight [BW]\/day), mean (\u00b1SD) iron absorption was 1.10 (\u00b10.28)\u2009mg\/day. During supplementation, 0.55 (\u00b10.36) mg iron\/day was lost, equal to half of the amount of absorbed iron. Supplementation did not increase faecal haem\/porphyrin or biomarkers of enterocyte damage and gut or systemic inflammation. Using individual patient data, we examined iron dose, absorption and loss among all available long\u2010term iron isotopic studies of supplementation. Expressed in terms of body weight, daily iron loss was correlated significantly with iron absorption (Pearson's <jats:italic>r<\/jats:italic>\u2009=\u20090.66 [95% confidence interval 0.48\u20130.78]) but not with iron dose (<jats:italic>r<\/jats:italic>\u2009=\u20090.16 [95% CI \u22120.10\u20130.40]). The results of this study indicate that iron loss is increased with daily oral iron supplementation and may blunt the efficacy of iron supplements in children. This study was registered at ClinicalTrials.gov as NCT04721964.<\/jats:p>","DOI":"10.1111\/bjh.19319","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:39:10Z","timestamp":1706834350000},"page":"2057-2065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Stable iron (<scp><sup>58<\/sup>Fe<\/scp>) isotopic measurements in Kenyan toddlers during 3\u2009months of iron supplementation demonstrate that half of the iron absorbed is lost"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7080-0156","authenticated-orcid":false,"given":"Ambra","family":"Giorgetti","sequence":"first","affiliation":[{"name":"Laboratory of Human Nutrition ETH  Zurich Switzerland"},{"name":"MRC Human Immunology Unit MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital  Oxford 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