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The overall response rate (ORR) was 76.2% (<jats:italic>n<\/jats:italic>\u2009=\u200916) in 21 evaluable patients with no patient achieving a complete response (CR). The median duration of treatment was 15.6\u2009months, and after a median follow\u2010up time of 25.7\u2009months, the median progression\u2010free survival (PFS) was 22.9\u2009months. While the primary end\u2010point was not met (CR rate at any time) and 28.5% discontinued treatment due to toxicity, ibrutinib plus ixazomib led to a clinically meaningful ORR and PFS. 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