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Venous thromboembolic events (VTEs) were reported in 6% and arterial embolic events (AEEs) in 5% of patients, respectively, during a 55\u2010month median follow\u2010up. Lower albumin, lower eGFR, higher BM infiltration, soft tissue involvement, IMiD\u2010based therapy and prior thrombosis were associated with VTE risk. Prior thrombosis was the only independent prognostic variable (HR 9.3, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Coronary arterial disease, prior AEE, 24\u2010h proteinuria and higher platelet counts were associated with AEE risk. Significant bleeding events were reported in 9%, and associated mortality was 19%. Liver involvement, higher serum creatinine and higher baseline VWF:Ag levels were linked to bleeding risk. Using competing risk analysis, the cumulative probability of thrombosis\/bleeding was higher during the first year following diagnosis, but a stable lower risk for both events remained for the duration of follow\u2010up. In AL amyloidosis patients, the risk of thrombotic\/arterial embolic events is significant, but the bleeding risk is also high. A multiparametric assessment is required to initiate anti\u2010thrombotic or anti\u2010platelet therapy appropriately.<\/jats:p>","DOI":"10.1111\/bjh.19331","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T10:02:49Z","timestamp":1707300169000},"page":"1816-1824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Thrombotic and bleeding complications in patients with <scp>AL<\/scp> amyloidosis"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-8900","authenticated-orcid":false,"given":"Despina","family":"Fotiou","sequence":"first","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens  Athens 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