{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:53:42Z","timestamp":1791428022407,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Idiopathic multicentric Castleman disease (iMCD) is subclassified into iMCD\u2010thrombocytopenia, anasarca, reticulin fibrosis, renal dysfunction, organomegaly (TAFRO) and iMCD\u2010not otherwise specified (NOS) according to the Castleman Disease Collaborative Network (CDCN) consensus criteria. With a deeper understanding of iMCD, a group of patients with iMCD\u2010NOS characterised by polyclonal hypergammaglobulinaemia, plasmacytic\/mixed\u2010type lymph node histopathology and thrombocytosis has attracted attention. This group of patients has been previously described as having idiopathic plasmacytic lymphadenopathy (IPL). Whether these patients should be excluded from the current classification system lacks sufficient evidence. This retrospective analysis of 228 patients with iMCD\u2010NOS identified 103 (45.2%) patients with iMCD\u2010IPL. The clinical features and outcomes of patients with iMCD\u2010IPL and iMCD\u2010NOS without IPL were compared. Patients with iMCD\u2010IPL showed a significantly higher inflammatory state but longer overall survival. No significant difference in overall survival was observed between severe and non\u2010severe patients in the iMCD\u2010IPL group according to the CDCN severity classification. Compared with lymphoma\u2010like treatments, multiple myeloma\u2010like and IL\u20106\u2010blocking treatment approaches in the iMCD\u2010IPL group resulted in significantly higher response rates and longer time to the next treatment. These findings highlight the particularities of iMCD\u2010IPL and suggest that it should be considered a new subtype of iMCD\u2010NOS.<\/jats:p>","DOI":"10.1111\/bjh.19334","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T03:35:52Z","timestamp":1707968152000},"page":"1830-1837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Idiopathic multicentric Castleman disease (\n                    <scp>iMCD<\/scp>\n                    )\u2010idiopathic plasmacytic lymphadenopathy: A distinct subtype of\n                    <scp>iMCD<\/scp>\n                    \u2010not otherwise specified with different clinical features and better survival"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7249-2855","authenticated-orcid":false,"given":"Yu\u2010han","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Haematology Peking Union 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