{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:53:57Z","timestamp":1769590437591,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T00:00:00Z","timestamp":1708214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017592","name":"Key Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2018ZDXM\u2010SF\u2010039"],"award-info":[{"award-number":["2018ZDXM\u2010SF\u2010039"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2018JM7151"],"award-info":[{"award-number":["2018JM7151"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy targeting B\u2010cell maturation antigen (BCMA) has shown profound efficacy and manageable toxicity in patients with relapsed\/refractory multiple myeloma (RRMM). However, determining the best course of treatment for post\u2010CAR\u2010T therapy relapse remains a significant challenge. We conducted a retrospective analysis of patients from the phase I LEGEND\u20102 study (NCT03090659) enrolled at the Xi'an site, analysing the first salvage line of therapy and outcomes in patients with RRMM who progressed after receiving LCAR\u2010B38M CAR\u2010T therapy. Of 45 eligible patients, 34 (76%) had progressive disease (PD). Overall response rate (ORR) to salvage treatment was 50.0%. Median progression\u2010free survival (PFS) after starting salvage treatment was 16.3\u2009months. Median PFS of patients receiving proteasome inhibitor (PI)\u2010based combination therapy was longer (28.2\u2009months) than that of patients receiving a second BCMA CAR\u2010T (including LCAR\u2010B38M; 3.9\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.0022) or chemotherapy (1.67\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.0001). All patients with extramedullary disease at baseline (<jats:italic>n<\/jats:italic>\u2009=\u200911) progressed after CAR\u2010T therapy; ORR to salvage therapy was 25.0% and median PFS was 9.7\u2009months. In conclusion, salvage therapy in patients with PD after receiving LCAR\u2010B38M CAR\u2010T cells produced moderate efficacy, with better outcomes for PI\u2010based salvage regimens.<\/jats:p>","DOI":"10.1111\/bjh.19340","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T07:10:45Z","timestamp":1708326645000},"page":"1780-1789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes in patients with multiple myeloma receiving salvage treatment after <scp>BCMA<\/scp>\u2010specific <scp>CAR\u2010T<\/scp> therapy: A retrospective analysis of <scp>LEGEND<\/scp>\u20102"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-829X","authenticated-orcid":false,"given":"Rui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi 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Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Xi'an Key Laboratory of diagnosis and treatment of hematological diseases  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanggang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Xi'an Key Laboratory of diagnosis and treatment of hematological diseases  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Xi'an Key Laboratory of diagnosis and treatment of hematological diseases  Xi'an 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Biotherapy The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an  Shaanxi China"},{"name":"Department of Tumor and Immunology Precision Medical Institute, Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9683-4860","authenticated-orcid":false,"given":"Jianli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"National\u2010Local Joint Engineering Research Center of Biodiagnostics and Biotherapy The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an  Shaanxi 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