{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:38:25Z","timestamp":1790469505201,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009010","name":"Novartis Pharmaceuticals UK Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Few studies have reported the real\u2010world use of both romiplostim and eltrombopag in immune thrombocytopenia (ITP). TRAIT was a retrospective observational study aimed to evaluate the platelet responses and adverse effects associated with the use of these thrombopoietin receptor agonists (TPO\u2010RAs) in adult patients with ITP in the United Kingdom. Of 267 patients (median age at diagnosis, 48\u2009years) with ITP (primary ITP [<jats:italic>n<\/jats:italic>\u2009=\u2009218], secondary ITP [<jats:italic>n<\/jats:italic>\u2009=\u200949]) included in the study, 112 (42%) received eltrombopag and 155 (58%) received romiplostim as the first prescribed TPO\u2010RA. A platelet count \u226530\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L was achieved in 89% of patients with the first TPO\u2010RA treatments, while 68% achieved a platelet count \u2265100\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L. Treatment\u2010free response (TFR; platelet count \u226530\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, 3\u2009months after discontinuing treatment) was achieved by 18% of the total patients. Overall, 61 patients (23%) switched TPO\u2010RAs, most of whom achieved platelet counts \u226530\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L with the second TPO\u2010RA (23\/25 who switched from eltrombopag to romiplostim [92%]; 28\/36 who switched from romiplostim to eltrombopag [78%]). TFR was associated with secondary ITP, early TPO\u2010RA initiation after diagnosis, the presence of comorbidity and no prior splenectomy or treatment with steroids or mycophenolate mofetil. Both TPO\u2010RAs had similar efficacy and safety profiles to those reported in clinical studies.<\/jats:p>","DOI":"10.1111\/bjh.19345","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T23:59:10Z","timestamp":1709337550000},"page":"2442-2452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Real\u2010world use of thrombopoietin receptor agonists for the management of immune thrombocytopenia in adult patients in the United Kingdom: Results from the <scp>TRAIT<\/scp> study"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9845-8292","authenticated-orcid":false,"given":"Nichola","family":"Cooper","sequence":"first","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2443-6517","authenticated-orcid":false,"given":"Marie","family":"Scully","sequence":"additional","affiliation":[{"name":"Haematology Programme NIHR UCLH\/UCL BRC  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Percy","sequence":"additional","affiliation":[{"name":"University Hospital Birmingham NHS Foundation Trust  Birmingham UK"},{"name":"Queen Elizabeth Hospital  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip L. 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