{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:43:28Z","timestamp":1783683808335,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022KY1184"],"award-info":[{"award-number":["2022KY1184"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY1601"],"award-info":[{"award-number":["2024KY1601"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY1602"],"award-info":[{"award-number":["2024KY1602"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A chemotherapy\u2010based mobilization regimen in patients who mobilize poorly, based on etoposide, cytarabine and pegfilgrastim (EAP), has recently been introduced. The aim of this prospective study was to investigate the efficacy and safety of the EAP regimen in patients with poorly mobilizing multiple myeloma (MM) or lymphoma. This single\u2010arm clinical trial was performed at eight public hospitals in China and was registered as a clinical trial (NCT05510089). The inclusion criteria were; (1) diagnosis of MM or lymphoma, (2) defined as a \u2018poor mobilizer\u2019 and (3) aged 18\u201375\u2009years. The EAP regimen consisted of etoposide 75\u2009mg\/m<jats:sup>2<\/jats:sup>\/day on days 1\u20132, cytarabine 300\u2009mg\/m<jats:sup>2<\/jats:sup> every 12\u2009h on days 1\u20132 and pegfilgrastim 6\u2009mg on day 6. The primary endpoint of the study was the ratio of patients achieving adequate mobilization (\u22652.0\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> CD34<jats:sup>+<\/jats:sup> cells\/kg). From 1 September 2022 to 15 August 2023, a total of 58 patients were enrolled, 53 (91.4%) achieved adequate mobilization, while 41 (70.7%) achieved optimal mobilization with a median number of cumulative collected CD34<jats:sup>+<\/jats:sup> cells was 9.2 (range 2.1\u201392.7)\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg and the median number of apheresis per patient of 1.2. The median time from administration of the EAP regimen to the first apheresis was 12\u2009days. Approximately 8.6% of patients required plerixa for rescue, which was successful. Twelve (20.7%) of the 58 patients suffered grade 2\u20133 infections, while 25 (43.1%) required platelet transfusions. The duration of neutrophil and platelet engraftment was 11\u2009days. In conclusion, these results suggest that the EAP mobilization regimen might be a promising option for poorly mobilizing patients with MM or lymphoma.<\/jats:p>","DOI":"10.1111\/bjh.19367","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T02:15:20Z","timestamp":1708740920000},"page":"2342-2350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Etoposide combined with cytarabine and pegfilgrastim for poorly mobilizing patients with multiple myeloma and lymphoma: A prospective multicentre study"],"prefix":"10.1111","volume":"204","author":[{"given":"Peipei","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang China"},{"name":"Institute of Hematology Ningbo University  Ningbo Zhejiang 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