{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:05:54Z","timestamp":1790697954838,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To address the lack of contemporary population\u2010based epidemiological studies of hepatosplenic T\u2010cell lymphoma (HSTCL), we undertook a population\u2010based study of ICD\u2010O\u20103\u2010coded HSTCL in England. We used the National Cancer Registration Dataset and linked datasets on hospital admissions, Systemic Anti\u2010Cancer Therapy, socio\u2010demographics, comorbidities and death, identifying cases from 1 January 2013 to 31 December 2019 with survival data up to 5 January 2021. Crude and directly age\u2010standardised incidence rates per million persons per year were calculated. Crude and adjusted incidence rate ratios compared incidence between groups using Poisson regression. A Cox proportional hazards model estimated mortality risks adjusted for age, sex, ethnicity, deprivation and allogenic stem cell transplant (allo\u2010SCT; time varying). We identified 44 patients, mean age 42\u2009years. Median survival was 11\u2009months, and 1 and 5 year survivals were 48% (95% CI 29%\u201343%) and 22% (95% CI 12%\u201342%) respectively. The age\u2010standardised incidence was 0.1 per million\/year. Incidence was higher in areas with greater deprivation (0.15 per million\/year), and more cases than expected were in non\u2010White patients (39%). Non\u2010Whites had a twofold increased risk of death (adjusted hazard ratio 2.21 [95% CI 1.03\u20134.78]) even after adjusting for deprivation, younger age and allo\u2010SCT. In conclusion, ethnicity and socio\u2010economic status affect both the incidence and survival of HSTCL.<\/jats:p>","DOI":"10.1111\/bjh.19371","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T04:05:43Z","timestamp":1709179543000},"page":"2222-2226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ethnicity and socio\u2010economic status affects the incidence and survival of hepatosplenic T\u2010cell lymphoma"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6058-1036","authenticated-orcid":false,"given":"Mark J.","family":"Bishton","sequence":"first","affiliation":[{"name":"University of Nottingham  Nottingham UK"},{"name":"Nottingham University Hospitals NHS Trust  Nottingham UK"},{"name":"National Disease Registration Service NHS England  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin J.","family":"Crooks","sequence":"additional","affiliation":[{"name":"University of Nottingham  Nottingham UK"},{"name":"Nottingham University Hospitals NHS Trust  Nottingham UK"},{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Card","sequence":"additional","affiliation":[{"name":"University of Nottingham  Nottingham UK"},{"name":"Nottingham University Hospitals NHS Trust  Nottingham UK"},{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1135-9356","authenticated-orcid":false,"given":"Joe","family":"West","sequence":"additional","affiliation":[{"name":"University of Nottingham  Nottingham UK"},{"name":"Nottingham University Hospitals NHS Trust  Nottingham UK"},{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham  Nottingham UK"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.01.005"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"160","article-title":"Hepatosplenic T\u2010cell lymphoma: a population\u2010based study assessing incidence and association with immune\u2010mediated disease","volume":"11","author":"Montgomery M","year":"2015","journal-title":"Gastroenterol Hepatol (NY)"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25674"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000614"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2010.05.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.280"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn751"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx015"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz076"},{"key":"e_1_2_10_13_1","unstructured":"Gov.UK.Population of England and Wales. [cited 2024 Jan 17]. Available from:https:\/\/www.ethnicity\u2010facts\u2010figures.service.gov.uk\/uk\u2010population\u2010by\u2010ethnicity\/national\u2010and\u2010regional\u2010populations\/population\u2010of\u2010england\u2010and\u2010wales\/latest"},{"key":"e_1_2_10_14_1","unstructured":"[cited 2024 Jan 17]. Available from:https:\/\/webarchive.nationalarchives.gov.uk\/ukgwa\/20160106020035\/http:\/\/www.ons.gov.uk\/ons\/guide\u2010method\/user\u2010guidance\/health\u2010and\u2010life\u2010events\/revised\u2010european\u2010standard\u2010population\u20102013\u2010\u20102013\u2010esp\u2010\/index.html"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T10:08:52Z","timestamp":1754993332000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,29]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/bjh.19371"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19371","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,29]]},"assertion":[{"value":"2023-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}