{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:38:27Z","timestamp":1788615507565,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hepatitis C virus (HCV)\u2010associated diffuse large B\u2010cell lymphoma (DLBCL) displays peculiar clinicopathological characteristics, but its molecular landscape is not fully elucidated. In this study, we investigated the clinicopathological and molecular features of 54 patients with HCV\u2010associated DLBCL. The median age was 71\u2009years. An underlying marginal zone lymphoma component was detected in 14.8% of cases. FISH analysis showed rearrangements involving <jats:italic>BCL6<\/jats:italic> in 50.9% of cases, <jats:italic>MYC<\/jats:italic> in 11.3% and <jats:italic>BCL2<\/jats:italic> in 3.7%. Lymph2Cx\u2010based assay was successful in 38 cases, recognizing 16 cases (42.1%) as ABC and 16 cases as GCB subtypes, while six resulted unclassified. ABC cases exhibited a higher lymphoma\u2010related mortality (LRM). Next\u2010generation sequencing analysis showed mutations in 158\/184 evaluated genes. The most frequently mutated genes were <jats:italic>KMT2D<\/jats:italic> (42.6%), <jats:italic>SETD1B<\/jats:italic> (33.3%), <jats:italic>RERE<\/jats:italic> (29.4%), <jats:italic>FAS<\/jats:italic> and <jats:italic>PIM1<\/jats:italic> (27.8%) and <jats:italic>TBL1XR1<\/jats:italic> (25.9%). A mutation in the NOTCH pathway was detected in 25.9% of cases and was associated with worst LRM. Cluster analysis by <jats:italic>LymphGen<\/jats:italic> classified 29\/54 cases within definite groups, including BN2 in 14 (48.2%), ST2 in seven (24.2%) and MCD and EZB in four each (13.8%). Overall, these results indicate a preferential marginal zone origin for a consistent subgroup of HCV\u2010associated DLBCL cases and suggest potential implications for molecularly targeted therapies.<\/jats:p>","DOI":"10.1111\/bjh.19378","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T19:49:37Z","timestamp":1709668177000},"page":"2242-2253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Molecular characterization of diffuse large B\u2010cell lymphomas associated with hepatitis C virus infection"],"prefix":"10.1111","volume":"204","author":[{"given":"Roberta","family":"Sciarra","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine University of Pavia  Pavia Italy"},{"name":"Division of Hematology Fondazione IRCCS Policlinico San Matteo  Pavia 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