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Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The second revision of the International Staging System (R2\u2010ISS) is a simple tool to risk\u2010stratify newly diagnosed multiple myeloma (NDMM) patients. Here, we completed a retrospective analysis to evaluate the utility of R2\u2010ISS in NDMM patients who underwent up\u2010front autologous haematopoietic stem cell transplantation (auto\u2010HCT). A total of 1291 patients were included, with a median age of 62\u2009years (range 29\u201383). The distribution of R2\u2010ISS stages was: 123 (10%) stage I, 471 (36%) stage II, 566 (44%) stage III and 131 (10%) stage IV. With a median follow\u2010up of 42.2\u2009months (range 0.3\u2013181.0), the median PFS was 73.0, 65.2, 44.0 and 24.8\u2009months, (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and the median OS was 130.8, 128.5, 94.2 and 61.4\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) for patients with R2\u2010ISS stages I, II, III and IV respectively. On multivariable analysis (MVA) for PFS, using R2\u2010ISS stage I as reference, R2\u2010ISS stages III (hazard ratio [95% confidence interval], 1.55 [1.05\u20132.29]; <jats:italic>p<\/jats:italic>\u2009=\u20090.028) and IV (2.04 [1.24\u20133.36]; <jats:italic>p<\/jats:italic>\u2009=\u20090.005) were associated with significantly inferior PFS. In the MVA of OS, using R2\u2010ISS stage I as reference, only R2\u2010ISS stage IV was associated with significantly inferior OS (2.43 [1.18\u20135.01]; <jats:italic>p<\/jats:italic>\u2009=\u20090.017). Overall, we found that R2\u2010ISS is a reliable prognostic tool for NDMM patients undergoing up\u2010front auto\u2010HCT.<\/jats:p>","DOI":"10.1111\/bjh.19384","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T01:20:00Z","timestamp":1709774400000},"page":"1944-1952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of revised International Staging System 2 risk stratification on outcomes of patients with multiple myeloma receiving autologous haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"204","author":[{"given":"Kamal","family":"Alzahrani","sequence":"first","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Adult Hematology and Bone Marrow Transplant, King Fahad Medical City (KFMC)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Pasvolsky","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Den\u00e1i R.","family":"Milton","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6516-0166","authenticated-orcid":false,"given":"Mark R.","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-6453","authenticated-orcid":false,"given":"Qaiser","family":"Bashir","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6693-2025","authenticated-orcid":false,"given":"Samer","family":"Srour","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8984-3420","authenticated-orcid":false,"given":"Jeremy","family":"Ramdial","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6034-8939","authenticated-orcid":false,"given":"Yago","family":"Nieto","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8545-3292","authenticated-orcid":false,"given":"Hans C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krina K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet E.","family":"Manasanch","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partow","family":"Kebriaei","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation 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second revision of the International Staging System (R2\u2010ISS) stratifies progression\u2010free and overall survival in multiple myeloma: real world data results in an Australian and New Zealand population","volume":"200","author":"Tan JLC","year":"2022","journal-title":"Br J Haematol"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3090"},{"issue":"4","key":"e_1_2_11_26_1","article-title":"The R2\u2010ISS in a multicenter cohort of Chinese patients with newly diagnosed multiple myeloma","volume":"7","author":"Yang 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