{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:32:02Z","timestamp":1784367122264,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Primary gastrointestinal follicular lymphoma (PGI\u2010FL) is a rare extra\u2010nodal lymphoma. Its epidemiology and prognosis remain unclear. We performed a retrospective analysis of eligible patients with 1648 PGI\u2010FL and 34\u2009892 nodal FL (N\u2010FL) in the Surveillance, Epidemiology and End Results (SEER) database. The age\u2010adjusted average annual incidence of PGI\u2010FL was 0.111\/100000. The median overall survival (OS) for PGI\u2010FL and N\u2010FL patients was 207 and 165\u2009months respectively. The 5\u2010year diffuse large B\u2010cell lymphoma (DLBCL) transformation rates were 2.1% and 2.6% respectively. Age, sex, grade, Ann Arbor stage, primary site and radiation were independent prognostic factors (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Nomograms were constructed to predict 1\u2010, 5\u2010 and 10\u2010year OS and disease\u2010specific survival (DSS). The receiver operating characteristic curves and calibration plots showed the established nomograms had robust and accurate performance. Patients were classified into three risk groups according to nomogram score. In conclusion, the incidence of PGI\u2010FL has increased over the past 40\u2009years, and PGI\u2010FL has a better prognosis and a lower DLBCL transformation rate than N\u2010FL. The nomograms were developed and validated as an individualized tool to predict survival. Patients were divided into three risk groups to assist clinicians in identifying high\u2010risk patients and choosing the optimal individualized treatments.<\/jats:p>","DOI":"10.1111\/bjh.19393","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T01:06:09Z","timestamp":1709773569000},"page":"1771-1779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Epidemiological features and prognosis for primary gastrointestinal follicular lymphoma"],"prefix":"10.1111","volume":"204","author":[{"given":"Xuelei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Lymphoma and National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, The Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, The Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrui","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, The Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology and Division of Pediatric Blood Diseases Center Institute of Hematology and Blood Diseases Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, The Sino\u2010US Center for Lymphoma and Leukemia Research  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Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, The Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key 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Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, The Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzi","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, The Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and 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