{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:06:28Z","timestamp":1783609588778,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In patients with sickle cell disease (SCD), SCD\u2010related cardiomyopathy may be partly due to repeated ischaemic events related to sickling during vaso\u2010occlusive crises, but few clinical studies support this hypothesis. We evaluated the incidence of acute myocardial ischaemia during vaso\u2010occlusive crises as assessed by the left ventricular global longitudinal strain (LVGLS) and high\u2010sensitive cardiac troponin T (hs\u2010cTnT). We included adult patients with SCD admitted to the intensive care unit (ICU) for vaso\u2010occlusive crisis. We collected hs\u2010cTnT and measured LVGLS with echocardiography at admission (day 1), day\u20092, day\u20093 and ICU discharge. Among 55 patients included, considering only the first hospitalization of patients admitted several times, 3 (5%) had elevated hs\u2010cTnT at \u22651 time point of the ICU stay. It was \u22642 times the upper limit of normal in two of these patients. LVGLS was altered at \u22651 time point of the ICU stay in 13 (24%) patients. Both hs\u2010cTnT and LVGLS were abnormal at \u22651 time point of the hospital stay in 2 (4%) patients. Acute myocardial injury as assessed by troponin elevation and LVGLS impairment was a rare event during vaso\u2010occlusive crises.<\/jats:p>","DOI":"10.1111\/bjh.19394","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:33:15Z","timestamp":1710289995000},"page":"2007-2015","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Left ventricular global longitudinal strain and acute myocardial injury in patients with sickle cell disease admitted to the intensive care unit for vaso\u2010occlusive crisis"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8310-7919","authenticated-orcid":false,"given":"Guillaume","family":"Roger","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Intensive\u2010R\u00e9animation, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 4 CORREVE Maladies du C\u0153ur et des Vaisseaux, Inserm UMR_S999, FHU SEPSIS, Groupe de Recherche CARMAS  Le Kremlin\u2010Bic\u00eatre France"},{"name":"Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Denormandie","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive\u2010R\u00e9animation, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 4 CORREVE Maladies du C\u0153ur et des Vaisseaux, Inserm UMR_S999, FHU SEPSIS, Groupe de Recherche CARMAS  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"Gobe","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive\u2010R\u00e9animation, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 4 CORREVE Maladies du C\u0153ur et des Vaisseaux, Inserm UMR_S999, FHU SEPSIS, Groupe de Recherche CARMAS  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danila","family":"Azzolina","sequence":"additional","affiliation":[{"name":"Department of Environmental and Preventive Science University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e0i","family":"Pham","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive\u2010R\u00e9animation, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 4 CORREVE Maladies du C\u0153ur et des Vaisseaux, Inserm UMR_S999, FHU SEPSIS, Groupe de Recherche CARMAS  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Chantalat","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne et Immunologie Clinique, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 7 Endocrinologie\u2010Immunit\u00e9s\u2010Inflammations\u2010Cancer\u2010Urgences  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphn\u00e9e","family":"Cuveillier","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne et Immunologie Clinique, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 7 Endocrinologie\u2010Immunit\u00e9s\u2010Inflammations\u2010Cancer\u2010Urgences  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Bouchachi","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 4 CORREVE Maladies du C\u0153ur et des Vaisseaux, Inserm UMR_S999  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Jourdain","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 4 CORREVE Maladies du C\u0153ur et des Vaisseaux, Inserm UMR_S999  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Lai","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive\u2010R\u00e9animation, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 4 CORREVE Maladies du C\u0153ur et des Vaisseaux, Inserm UMR_S999, FHU SEPSIS, Groupe de Recherche CARMAS  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Pavot","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive\u2010R\u00e9animation, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 4 CORREVE Maladies du C\u0153ur et des Vaisseaux, Inserm UMR_S999, FHU SEPSIS, Groupe de Recherche CARMAS  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Fage","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive\u2010R\u00e9animation, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 4 CORREVE Maladies du C\u0153ur et des Vaisseaux, Inserm UMR_S999, FHU SEPSIS, Groupe de Recherche CARMAS  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Domnariu","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne et Immunologie Clinique, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 7 Endocrinologie\u2010Immunit\u00e9s\u2010Inflammations\u2010Cancer\u2010Urgences  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Teboul","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive\u2010R\u00e9animation, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 4 CORREVE Maladies du C\u0153ur et des Vaisseaux, Inserm UMR_S999, FHU SEPSIS, Groupe de Recherche CARMAS  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Monnet","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive\u2010R\u00e9animation, AP\u2010HP, H\u00f4pital de Bic\u00eatre, Universit\u00e9 Paris\u2010Saclay, DMU 4 CORREVE Maladies du C\u0153ur et des Vaisseaux, Inserm UMR_S999, FHU SEPSIS, Groupe de Recherche CARMAS  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24235"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-716910"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2020.08.009"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-014-0473-1"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.05.013"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005565"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz217"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600311113"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-02-767624"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.271254"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2012.07.021"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200710-1606OC"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.11.017"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2012.01784.x"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086959"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-016-1006-x"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-383430"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(15)60002-9"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.07.020"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28973"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0375-9393.18.12249-8"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.038"},{"key":"e_1_2_15_25_1","volume-title":"R: A language and environment for statistical \u00a0 Computing","author":"R Core Team","year":"2023"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-021-02414-6"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.358"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15238"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1983.00350040220037"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830160206"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200312000-00015"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-198806000-00012"},{"issue":"3","key":"e_1_2_15_33_1","first-page":"209","article-title":"Sickle cell anaemia: does myocardial ischemia occur during crisis?","volume":"83","author":"Norris S","year":"1991","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.11.165"},{"issue":"10","key":"e_1_2_15_35_1","first-page":"1329","article-title":"Myocardial ischemia and right ventricular dysfunction in adult patients with sickle cell disease","volume":"91","author":"Raman SV","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.08.135"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.04.084"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-018-3231-x"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3623-6"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517540"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21569"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164526"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.032920"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035477"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T08:44:09Z","timestamp":1730709849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,12]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/bjh.19394"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19394","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,12]]},"assertion":[{"value":"2023-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}