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The effect of COVID\u201019 vaccination on splenectomized patients with ITP during the COVID\u201019 pandemic has not been reported. Therefore, this study aimed to investigate the effect of COVID\u201019 vaccination on clinical outcomes in these patients. This was a longitudinal study of splenectomized patients with ITP. A total of 191 splenectomized patients were included in this study. After a median follow\u2010up of 114\u2009months, 146 (76.4%) patients had a sustained response to splenectomy. During COVID\u201019 infection, vaccinated patients showed a lower risk of severe infections (odds ratio [OR], 0.13; 95% confidence interval [CI]: 0.05\u20130.36; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), hospitalization (OR, 0.13; 95% CI, 0.04\u20130.48; <jats:italic>p<\/jats:italic>\u2009=\u20090.002), and ITP exacerbation (OR, 0.16; 95% CI, 0.04\u20130.67; <jats:italic>p<\/jats:italic>\u2009=\u20090.012). These findings indicate that COVID\u201019 vaccination plays a protective role in splenectomized patients with ITP.<\/jats:p>","DOI":"10.1111\/bjh.19405","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T23:55:01Z","timestamp":1713398101000},"page":"2217-2221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Protective effects of <scp>COVID<\/scp>\u201019 vaccination in splenectomized patients with immune thrombocytopenia"],"prefix":"10.1111","volume":"204","author":[{"given":"Xiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0166-2180","authenticated-orcid":false,"given":"Xinai","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu China"},{"name":"West China School of Medicine, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1595-2138","authenticated-orcid":false,"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu China"},{"name":"West China School of Medicine, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanchong Central Hospital  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2437-9348","authenticated-orcid":false,"given":"Yuping","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery West China Hospital, Sichuan University  Chengdu 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