{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:54:03Z","timestamp":1759776843217,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K16248"],"award-info":[{"award-number":["21K16248"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Immune thrombocytopenia (ITP) is characterized by early platelet destruction and impaired platelet production. <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection seems to contribute to the pathogenesis in certain ITP patients in Japan. We compared the effectiveness of platelet transfusion in severe ITP in the presence or absence of <jats:italic>H.\u00a0pylori<\/jats:italic>. The median corrected count increment (CCI) at 24\u2009h after platelet transfusion (CCI\u201024) of the <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive ITP patients was higher than that of the <jats:italic>H. pylori<\/jats:italic>\u2010negative ITP patients (6463 vs. 754, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and the CCI\u20101 was also in the same direction but not significant (23\u2009351 vs. 11\u2009578). Multiple regression analyses showed that <jats:italic>H. pylori<\/jats:italic> infection was independently associated with CCI\u201024. Our study suggests that platelet transfusion may be more effective in <jats:italic>H. pylori<\/jats:italic>\u2010positive ITP patients.<\/jats:p>","DOI":"10.1111\/bjh.19413","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:48:45Z","timestamp":1711327725000},"page":"1953-1957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of platelet transfusion effectiveness between <i>Helicobacter pylori<\/i>\u2010positive and \u2010negative immune thrombocytopenia"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6240-4391","authenticated-orcid":false,"given":"Shotaro","family":"Tabata","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology Wakayama Medical University  Wakayama Japan"},{"name":"Department of Internal Medicine Kainan Municipal Medical Center  Wakayama 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