{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:31:31Z","timestamp":1783521091221,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011353","name":"Center for Clinical and Translational Science, University of Massachusetts","doi-asserted-by":"publisher","award":["UL1TR001453"],"award-info":[{"award-number":["UL1TR001453"]}],"id":[{"id":"10.13039\/100011353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Recursive partitioning of healthy consortia led to the development of the Clonal Hematopoiesis Risk Score (CHRS) for clonal haematopoiesis (CH); however, in the practical setting, most cases of CH are diagnosed after patients present with cytopenias or related symptoms. To address this real\u2010world population, we characterize the clinical trajectories of 94 patients with CH and distinguish CH harbouring canonical <jats:italic>DNMT3A\/TET2\/ASXL1<\/jats:italic> mutations alone (\u2018sole DTA\u2019) versus all other groups (\u2018non\u2010sole DTA\u2019). <jats:italic>TET2<\/jats:italic>, rather than <jats:italic>DNMT3A<\/jats:italic>, was the most prevalent mutation in the real\u2010world setting. Sole DTA patients did not progress to myeloid neoplasm (MN) in the absence of acquisition of other mutations. Contrastingly, 14 (20.1%) of 67 non\u2010sole DTA patients progressed to MN. CHRS assessment showed a higher frequency of high\u2010risk CH in non\u2010sole DTA (vs. sole DTA) patients and in progressors (vs. non\u2010progressors). <jats:italic>RUNX1<\/jats:italic> mutation conferred the strongest risk for progression to MN (odds ratio [OR] 10.27, 95% CI 2.00\u201352.69, <jats:italic>p<\/jats:italic>\u2009=\u20090.0053). The mean variant allele frequency across all genes was higher in progressors than in non\u2010progressors (36.9%\u2009\u00b1\u20094.62% vs. 24.1%\u2009\u00b1\u20091.67%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0064). This analysis in the post\u2010CHRS era underscores the natural history of CH, providing insight into patterns of progression to MN.<\/jats:p>","DOI":"10.1111\/bjh.19423","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T01:05:05Z","timestamp":1711328705000},"page":"1844-1855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Natural history of clonal haematopoiesis seen in real\u2010world haematology settings"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8208-1902","authenticated-orcid":false,"given":"Shyam A.","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine UMass Memorial Medical Center, UMass Chan Medical School  Worcester Massachusetts USA"},{"name":"Center for Clinical and Translational Science UMass Chan Medical School  Worcester Massachusetts 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