{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:19:01Z","timestamp":1770358741622,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Therapy\u2010related acute lymphoblastic leukaemia (tr\u2010ALL) is a disease entity attributed to previous exposure to chemotherapy and\/or radiation for antecedent malignancy. There is observed female predominance for tr\u2010ALL, likely due to high prevalence and excellent curable rate for non\u2010metastatic breast cancer as well as the frequent use of carcinogenic agents as part of adjuvant therapy. Here, we reviewed 37 women with diagnosis of ALL following breast cancer treatment with focus on cytogenetic categorization. Philadelphia chromosome positivity (Ph+), <jats:italic>KMT2A<\/jats:italic> alterations and other cytogenetic change groups were observed in 32%, 22% and 46% of patients respectively. Median overall survival (OS) and relapse\u2010free survival (RFS) were 19.4 and 12.9\u2009months, overall while both OS and RFS were superior in tr\u2010ALL with Ph+ disease compared to <jats:italic>KMT2Ar<\/jats:italic> and other cytogenetics respectively. Seventeen (45.9%) patients underwent consolidative allogeneic haematopoietic cell transplantation (alloHCT) in CR1 out of which 4 (24%) relapsed following transplant. Both OS and RFS were superior in the <jats:italic>KMT2Ar<\/jats:italic> cytogenetics group following alloHCT. Ph chromosome represents the largest genetic entity of tr\u2010ALL following breast cancer therapy, and it may be associated with superior survival outcomes while <jats:italic>KMT2Ar<\/jats:italic> may be associated with poorer outcomes that can perhaps be mitigated by alloHSCT.<\/jats:p>","DOI":"10.1111\/bjh.19432","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T02:05:36Z","timestamp":1711937136000},"page":"158-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapy\u2010related acute lymphoblastic leukaemia in women with antecedent breast cancer"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3862-4612","authenticated-orcid":false,"given":"Hoda","family":"Pourhassan","sequence":"first","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center  Duarte California 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Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-5320","authenticated-orcid":false,"given":"Paul","family":"Koller","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8226-471X","authenticated-orcid":false,"given":"Monzr","family":"Al\u00a0Malki","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-3176","authenticated-orcid":false,"given":"Ahmed","family":"Aribi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-5041","authenticated-orcid":false,"given":"Amandeep","family":"Salhotra","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karamjeet","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haris","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Marcucci","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center  Duarte California 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