{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:52:31Z","timestamp":1789199551821,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010824","name":"Associazione Angela Serra per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007386","name":"Fondazione Cassa di Risparmio di Modena","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Peripheral T\u2010cell lymphomas (PTCLs) are a heterogeneous group of haematological cancers with generally poor clinical outcomes. However, a subset of patients experience durable disease control, and little is known regarding long\u2010term outcomes. The International T\u2010cell Lymphoma Project (ITCLP) is the largest prospectively collected cohort of patients with PTCLs, providing insight into clinical outcomes at academic medical centres globally. We performed a long\u2010term outcome analysis on patients from the ITCLP with available 10\u2010year follow\u2010up data (<jats:italic>n<\/jats:italic>\u2009=\u2009735). The overall response rate to first\u2010line therapy was 68%, while 5\u2010 and 10\u2010year overall survival estimates were 49% and 40% respectively. Most deaths occurred prior to 5\u2009years, and for patients alive at 5\u2009years, the chance of surviving to 10\u2009years was 84%. However, lymphoma remained the leading cause of death in the 5\u2010 to 10\u2010year period (67%). Low\u2010risk International Prognostic Index and Prognostic Index for T\u2010cell lymphoma scores both identified patients with improved survival, while in multivariate analysis, age &gt;60\u2009years and Eastern Cooperative Oncology Group performance status 2\u20134 were associated with inferior outcomes. The favourable survival seen in patients achieving durable initial disease control emphasizes the unmet need for optimal front\u2010line therapeutic approaches in PTCLs.<\/jats:p>","DOI":"10.1111\/bjh.19433","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T01:50:38Z","timestamp":1711504238000},"page":"166-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term outcome of peripheral T\u2010cell lymphomas: Ten\u2010year follow\u2010up of the International Prospective T\u2010cell Project"],"prefix":"10.1111","volume":"205","author":[{"given":"Monica","family":"Civallero","sequence":"first","affiliation":[{"name":"CHIMOMO Department University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4128-2537","authenticated-orcid":false,"given":"Joseph G.","family":"Schroers\u2010Martin","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6399-2006","authenticated-orcid":false,"given":"Steven","family":"Horwitz","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan\u2010Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Manni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Children and Adults University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7884-193X","authenticated-orcid":false,"given":"Yana","family":"Stepanishyna","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplant National Cancer Institute  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Hematolog\u00eda, Hospital del Salvador Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Vose","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Spina","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Immune\u2010Related Tumors, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS  Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicitas","family":"Hitz","sequence":"additional","affiliation":[{"name":"Department of Oncology\/Haematology, The Swiss Group for Clinical Cancer Research Cantonal Hospital  St Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-1265","authenticated-orcid":false,"given":"Arnon","family":"Nagler","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Montoto","sequence":"additional","affiliation":[{"name":"Department of Haemato\u2010Oncology, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Chiattone","sequence":"additional","affiliation":[{"name":"Higienopolis and Santa Casa Medical School of Sao Paulo Samaritano Hospital  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetiana","family":"Skrypets","sequence":"additional","affiliation":[{"name":"Hematology and Cell Therapy Department IRCCS Istituto Tumori Giovanni Paolo II  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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