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Two CAR\u2010T products, idecabtagene vicleucel (ide\u2010cel; Abecma) and ciltacabtagene autoleucel (cilta\u2010cel, Carvykti), have been FDA\u2010 and EMA\u2010approved for the treatment of relapsed\/refractory MM (RRMM); both target B\u2010cell maturation antigen (BCMA), a surface glycoprotein highly expressed on MM cells. Despite deep and durable responses following CAR\u2010T therapy, most patients will need subsequent treatment, and the optimal next\u2010line therapy is presently unclear.<\/jats:p><jats:p>Commentary on: Liu et\u00a0al. Outcomes in patients with multiple myeloma receiving salvage treatment after BCMA\u2010specific CAR\u2010T therapy: A retrospective analysis of LEGEND\u20102. 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