{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:27:04Z","timestamp":1790836024861,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Peripheral T\u2010cell lymphomas (PTCL) are morphologically and biologically heterogeneous and a subset expresses CD30, including anaplastic large cell lymphomas (ALCL) and a minority of PTCL, not otherwise specified (PTCL, NOS). ALCL with ALK translocations (ALCL, ALK+) are readily identified by routine diagnostic methods, but differentiating ALCL without ALK translocation (ALCL, ALK\u2212) and PTCL, NOS expressing CD30 (PTCL CD30+) can be challenging. Furthermore, rare PTCL co\u2010express CD30 and CD15 (PTCL CD30+CD15+); some resemble ALCL, ALK\u2212 while others resemble classic Hodgkin lymphoma. To explore the relationship between PTCL CD30+CD15+ and ALCL, ALK\u2212, we analysed 19 cases of PTCL with CD30 expression, previously diagnosed as ALCL, ALK\u2212 (nine cases) and PTCL CD30+CD15+ (10 cases) for DUSP22\/IRF4 rearrangements, coding RNA expression and selected transcriptome analysis using the NanoString nCounter gene expression analysis platform. Unsupervised clustering showed no clear segregation between ALCL, ALK\u2212 and PTCL CD30+CD15+. Three cases previously classified as PTCL CD30+CD15+ showed DUSP22\/IRF4 rearrangements, favouring a diagnosis of ALCL, ALK\u2212. Our results suggest that cases previously designated PTCL CD30+CD15+, likely fall within the spectrum of ALCL, ALK\u2212; additionally, a subset of ALCL, ALK\u2212 with DUSP22\/IRF4 rearrangement expresses CD15, consistent with previous reports and expands the immunophenotypic spectrum of this lymphoma subgroup.<\/jats:p>","DOI":"10.1111\/bjh.19442","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T05:55:06Z","timestamp":1712987706000},"page":"1862-1871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Peripheral T\u2010cell lymphomas expressing <scp>CD30<\/scp> and <scp>CD15<\/scp> expand the spectrum of anaplastic large cell lymphoma, <scp>ALK<\/scp>\u2010negative"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6090-1973","authenticated-orcid":false,"given":"Karthik 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