{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:59:04Z","timestamp":1790949544575,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100016387","name":"Grifols","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Immune thrombocytopenia (ITP) is characterized by low platelet counts (PLTs) and an increased risk of bleeding. Fostamatinib, a spleen tyrosine kinase inhibitor, has been approved as a second\u2010line treatment for ITP. Real\u2010world data on fostamatinib are lacking. This observational, retrospective, multicentre study, conducted in the Andalusia region of Spain, evaluated 44 adult primary ITP patients (47.7% female; median age 58\u2009years; newly diagnosed ITP 6.8%; persistent 13.6%; chronic 79.5%; median four prior treatments) after \u2265\u20094\u2009weeks of fostamatinib therapy. The median PLT at the initiation of fostamatinib was 15\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L. Common reasons for starting fostamatinib were refractoriness or intolerance to prior therapy, oral medication preference, history of thrombosis and cardiovascular risk. Dosing was individualized based on efficacy and tolerance. After 2 weeks, global response rate was 56.8% (response and complete response). Response rates were 70.5%, 62.5% and 64% at 4\u2009weeks, 12\u2009weeks and at the end of the study respectively. Adverse events were mild, and no patients discontinued as a result. This real\u2010world study demonstrated a response rate similar to fostamatinib as seen in the pivotal clinical trials while including newly diagnosed patients and allowing for individualized dosing.<\/jats:p>","DOI":"10.1111\/bjh.19443","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T07:25:00Z","timestamp":1712129100000},"page":"1977-1985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment with fostamatinib in patients with immune thrombocytopenia: Experience from the Andalusian region in Spain\u2014The Fostasur Study"],"prefix":"10.1111","volume":"204","author":[{"given":"Reyes","family":"Jim\u00e9nez\u2010B\u00e1rcenas","sequence":"first","affiliation":[{"name":"Hospital de la Serran\u00eda de Ronda  M\u00e1laga 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