{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:40:15Z","timestamp":1792806015643,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>CD7\u2010targeted chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy has shown promising initial complete remission (CR) rates in patients with refractory or relapsed (r\/r) T\u2010cell acute lymphoblastic leukaemia and lymphoblastic lymphoma (T\u2010ALL\/LBL). To enhance the remission duration, consolidation with allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) is considered. Our study delved into the outcomes of 34 patients with r\/r T\u2010ALL\/LBL who underwent allo\u2010HSCT after achieving CR with autologous CD7 CAR\u2010T therapy. These were compared with 124 consecutive T\u2010ALL\/LBL patients who received allo\u2010HSCT in CR following chemotherapy. The study revealed that both the CAR\u2010T and chemotherapy cohorts exhibited comparable 2\u2010year overall survival (OS) (61.9% [95% CI, 44.1\u201378.1] vs. 67.6% [95% CI, 57.5\u201376.9], <jats:italic>p<\/jats:italic>\u2009=\u20090.210), leukaemia\u2010free survival (LFS) (62.3% [95% CI, 44.6\u201378.4] vs. 62.0% [95% CI, 51.8\u201371.7], <jats:italic>p<\/jats:italic>\u2009=\u20090.548), non\u2010relapse mortality (NRM) rates (32.0% [95% CI, 19.0\u201354.0] vs. 25.3% [95% CI, 17.9\u201335.8], <jats:italic>p<\/jats:italic>\u2009=\u20090.288) and relapse incidence rates (8.8% [95% CI, 3.0\u201326.0] vs. 15.8% [95% CI, 9.8\u201325.2], <jats:italic>p<\/jats:italic>\u2009=\u20090.557). Patients aged \u226414 in the CD7 CAR\u2010T group achieved high 2\u2010year OS and LFS rates of 87.5%. Our study indicates that CD7 CAR\u2010T therapy followed by allo\u2010HSCT is not only effective and safe for r\/r T\u2010ALL\/LBL patients but also on par with the outcomes of those achieving CR through chemotherapy, without increasing NRM.<\/jats:p>","DOI":"10.1111\/bjh.19445","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T03:44:13Z","timestamp":1712979853000},"page":"2351-2364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A safety and efficacy study of allogeneic haematopoietic stem cell transplantation for refractory and relapsed T\u2010cell acute lymphoblastic leukaemia\/lymphoblastic lymphoma patients who achieved complete remission after autologous <scp>CD7<\/scp> chimeric antigen receptor T\u2010cell therapy"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-6456","authenticated-orcid":false,"given":"Xing\u2010yu","family":"Cao","sequence":"first","affiliation":[{"name":"Hebei Yanda Lu Daopei Hospital  Langfang China"},{"name":"Beijing Lu Daopei Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei Yanda Lu Daopei Hospital  Langfang China"},{"name":"Beijing Lu Daopei Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-8146","authenticated-orcid":false,"given":"Yue","family":"Lu","sequence":"additional","affiliation":[{"name":"Hebei Yanda Lu Daopei Hospital  Langfang China"},{"name":"Beijing Lu Daopei Hospital  Beijing 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