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A total of 130 Ann Arbor stage III or IV T\u2010LBL patients (&gt;16\u2009years) treated with allo\u2010HSCT across five transplant centres were enrolled. The 2\u2010year cumulative incidence of disease progression, the probabilities of progression\u2010free survival (PFS), overall survival (OS) and non\u2010relapse mortality (NRM) after allo\u2010HSCT were 21.0%, 69.8%, 79.5% and 9.2% respectively. Patients with central nervous system (CNS) involvement had a higher cumulative incidence of disease progression compared with those without CNS involvement (57.1% vs. 18.9%, HR 3.78, <jats:italic>p<\/jats:italic>\u2009=\u20090.014). Patients receiving allo\u2010HSCT in non\u2010remission (NR) had a poorer PFS compared with those receiving allo\u2010HSCT in complete remission (CR) or partial remission (49.2% vs. 72.7%, HR 2.21, <jats:italic>p\u2009=<\/jats:italic>\u20090.041). Particularly for patients with bone marrow involvement and achieving CR before allo\u2010HSCT, measurable residual disease (MRD) positivity before allo\u2010HSCT was associated with a poorer PFS compared with MRD negativity (62.7% vs. 86.8%, HR 1.94, <jats:italic>p<\/jats:italic>\u2009=\u20090.036). On multivariate analysis, CNS involvement at diagnosis and receiving allo\u2010HSCT in NR were associated with disease progression. Thus, our real\u2010world data suggested that allo\u2010HSCT appeared to be an effective therapy for adult T\u2010LBL patients with Ann Arbor stage III or IV disease.<\/jats:p>","DOI":"10.1111\/bjh.19481","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:44:27Z","timestamp":1714092267000},"page":"2390-2399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Allogeneic haematopoietic stem cell transplantation for adult T\u2010lymphoblastic lymphoma: A real\u2010world multicentre analysis in\u00a0China"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1392-2081","authenticated-orcid":false,"given":"Wenxuan","family":"Huo","sequence":"first","affiliation":[{"name":"Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking 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