{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:46:54Z","timestamp":1773215214565,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2020\u2010I2M\u2010C&T\u2010A\u2010020"],"award-info":[{"award-number":["2020\u2010I2M\u2010C&T\u2010A\u2010020"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2022\u2010I2M\u20101\u2010022"],"award-info":[{"award-number":["2022\u2010I2M\u20101\u2010022"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81530008"],"award-info":[{"award-number":["81530008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070134"],"award-info":[{"award-number":["82070134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104785"],"award-info":[{"award-number":["82104785"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170139"],"award-info":[{"award-number":["82170139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The criteria of myelodysplastic syndromes (MDS) with mutated <jats:italic>SFB31<\/jats:italic> (MDS\u2010<jats:italic>SFB31<\/jats:italic>) proposed by the 5th edition of the WHO classification (WHO 2022) and the International Consensus Classification (ICC) need validation. We analysed 125 consecutive MDS cases with <jats:italic>SFB31<\/jats:italic> mutation or ring sideroblasts (RS) \u226515% without excess blasts. We found that <jats:italic>SFB31<\/jats:italic>\u2010negative MDS with RS had significantly different clinical features and worse prognosis. According to WHO 2022, the detection of \u226515% RS may substitute for <jats:italic>SF3B1<\/jats:italic> mutation and our analyses support this proposal for similar prognosis of two groups after excluding high\u2010risk genetic features referred by WHO 2022. Patients with variant allele frequency (VAF) &lt;10% <jats:italic>SFB31<\/jats:italic> tend to have briefer survival, supporting the VAF 10% threshold of ICC. Patients with multilineage dysplasia (MLD) had significantly shorter OS than those with single lineage dysplasia. MLD is still a powerful morphological marker of worse outcome in WHO 2022 and ICC\u2010defined MDS\u2010<jats:italic>SF3B1<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/bjh.19482","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T04:23:42Z","timestamp":1713932622000},"page":"942-946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validation and comparison of 5th edition World Health Organization classification (<scp>WHO<\/scp> 2022) and International Consensus Classification proposals for MDS\u2010<i>SFB31<\/i>"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1044-5897","authenticated-orcid":false,"given":"Linlin","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, National Clinical Research Centre for Blood Diseases Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, National Clinical Research Centre for Blood Diseases Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"MDS and MPN Centre Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zefeng","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, National Clinical Research Centre for Blood Diseases Institute of Hematology and Blood Diseases 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Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, National Clinical Research Centre for Blood Diseases Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"MDS and MPN Centre Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, National Clinical Research Centre for Blood Diseases Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junying","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, National Clinical Research Centre for Blood Diseases Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Hematologic Pathology Centre Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Pan","sequence":"additional","affiliation":[{"name":"MDS and MPN Centre Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyan","family":"Gao","sequence":"additional","affiliation":[{"name":"MDS 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