{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:38Z","timestamp":1787013938136,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>MYH9<\/jats:italic>\n                    \u2010related disorder (\n                    <jats:italic>MYH9<\/jats:italic>\n                    \u2010RD) is characterized by congenital macrothrombocytopenia and granulocyte inclusion bodies.\n                    <jats:italic>MYH9<\/jats:italic>\n                    \u2010RD is often misdiagnosed as chronic immune thrombocytopenia. In this study, we investigated age at definitive diagnosis and indicative thrombocytopenia in 41 patients with\n                    <jats:italic>MYH9<\/jats:italic>\n                    \u2010RD from the congenital thrombocytopenia registry in Japan. Our cohort comprises 54.8% adults over 18\u2009years at confirmed diagnosis. We found a significant difference (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) between the median age at definitive diagnosis of 25.0\u2009years and for indicative thrombocytopenia it was 9.0\u2009years. Our findings strongly suggest diagnostic delay of\n                    <jats:italic>MYH9<\/jats:italic>\n                    \u2010RD in Japan. Our registry system will continue to contribute to this issue.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19484","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T01:23:26Z","timestamp":1713835406000},"page":"2400-2404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic delay of\n                    <scp>\n                      <i>MYH9<\/i>\n                    <\/scp>\n                    \u2010related disorder in Japan"],"prefix":"10.1111","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2222-5425","authenticated-orcid":false,"given":"Atsushi","family":"Sakamoto","sequence":"first","affiliation":[{"name":"Center for Postgraduate Education and Training National Center for Child Health and Development (NCCHD)  Tokyo Japan"},{"name":"Division of Haematology NCCHD  Tokyo 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Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaei","family":"Onum","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology Miyagi Children's Hospital  Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kunishima","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, School of Health Sciences Gifu University of Medical Science  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3896-5313","authenticated-orcid":false,"given":"Akira","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Center for Postgraduate Education and Training National Center for Child Health and Development (NCCHD)  Tokyo Japan"},{"name":"Division of Haematology NCCHD  Tokyo 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