{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:37Z","timestamp":1787013937424,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Diagnosing chronic myeloid leukaemia (CML) during pregnancy is rare. Tyrosine kinase inhibitors (TKIs) have traditionally been contraindicated owing to their teratogenicity. Management decisions should consider the risks to mother and foetus of uncontrolled disease and teratogenic medications. Further cases are required to build upon the paucity of current literature. We report 22 cases of CML diagnosed during pregnancy from 2002 to date. Twenty\u2010one pregnancies resulted in healthy babies and one patient miscarried. Some patients remained untreated throughout pregnancy but the majority received one or both of interferon\u2010\u03b1 and leucapheresis. One patient was started on imatinib at Week 26, and one on hydroxycarbamide in the third trimester. We report haematological parameters during pregnancy to provide clinicians with realistic expectations of management. There were no fetal abnormalities related to treatment during pregnancy. Seventeen patients achieved at least major molecular response on first\u2010line TKI. A diagnosis of CML during pregnancy can be managed without significant consequences for mother or child. Leucapheresis and interferon\u2010\u03b1 are generally safe throughout pregnancy. Despite having been avoided previously, there is growing evidence that certain TKIs may be used in particular circumstances during the later stages of pregnancy. Future work should aim to further elucidate this safety profile.<\/jats:p>","DOI":"10.1111\/bjh.19491","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T02:50:12Z","timestamp":1714704612000},"page":"947-955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Expectations and outcomes of varying treatment strategies for\n                    <scp>CML<\/scp>\n                    presenting during pregnancy"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2969-8081","authenticated-orcid":false,"given":"H. F.","family":"Robertson","sequence":"first","affiliation":[{"name":"Centre for Haematology, Imperial College London  London UK"},{"name":"Department of Clinical Haematology, Hammersmith Hospital Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Milojkovic","sequence":"additional","affiliation":[{"name":"Centre for Haematology, Imperial College London  London UK"},{"name":"Department of Clinical Haematology, Hammersmith Hospital Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Butt","sequence":"additional","affiliation":[{"name":"Royal Liverpool and Broadgreen University Teaching Hospitals NHS Trust  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Nottingham University Hospital NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Claudiani","sequence":"additional","affiliation":[{"name":"Centre for Haematology, Imperial College London  London UK"},{"name":"Department of Clinical Haematology, Hammersmith Hospital Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7655-016X","authenticated-orcid":false,"given":"M.","family":"Copland","sequence":"additional","affiliation":[{"name":"Paul O'Gorman Leukaemia Research Centre, School of Cancer Sciences, College of Medical, Veterinary and Life Sciences University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gallipoli","sequence":"additional","affiliation":[{"name":"Centre for Haemato\u2010Oncology Barts Cancer Institute, Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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