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First, we conducted a pharmacovigilance study to assess the reporting of atrial arrhythmias following CD19\u2010directed CAR\u2010T. Subsequently, to determine the incidence, risk factors and outcomes of atrial arrhythmias post\u2010CAR\u2010T, we compiled a retrospective single\u2010centre cohort of non\u2010Hodgkin lymphoma patients. Only commercial CAR\u2010T products were considered. Atrial arrhythmias were nearly fourfold more likely to be reported after CAR\u2010T therapy compared to all other cancer patients in the FAERS (adjusted ROR\u2009=\u20093.76 [95% CI 2.67\u20135.29]). Of the 236 patients in our institutional cohort, 23 (10%) developed atrial arrhythmias post\u2010CAR\u2010T, including 12 de novo arrhythmias, with most (83%) requiring medical intervention. Atrial arrhythmias frequently co\u2010occurred with cytokine release syndrome and were associated with higher post\u2010CAR\u2010T infusion peak levels of IL\u201010, TNF\u2010alpha and LDH, and lower trough levels of fibrinogen. In a multivariable analysis, risk factors for atrial arrhythmia were history of atrial arrhythmia (OR\u2009=\u20096.80 [2.39\u201319.6]) and using CAR\u2010T product with a CD28\u2010costimulatory domain (OR\u2009=\u20095.17 [1.72\u201318.6]). Atrial arrhythmias following CD19\u2010CAR\u2010T therapy are prevalent and associated with elevated inflammatory biomarkers, a history of atrial arrhythmia and the use of a CAR\u2010T product with a CD28 costimulatory domain.<\/jats:p>","DOI":"10.1111\/bjh.19497","type":"journal-article","created":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T20:58:52Z","timestamp":1715547532000},"page":"978-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Atrial arrhythmias following\n                    <scp>CAR\u2010chimeric<\/scp>\n                    antigen receptor T\u2010cell therapy: Incidence, risk factors and biomarker profile"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-8032","authenticated-orcid":false,"given":"Roni","family":"Shouval","sequence":"first","affiliation":[{"name":"Department of Medicine, Adult Bone Marrow Transplantation Service Memorial Sloan 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