{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:39:32Z","timestamp":1790775572881,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Idecabtagene vicleucel (ide\u2010cel), a chimeric antigen receptor T\u2010cell therapy targeting B\u2010cell maturation antigen (BCMA), received early access program (EAP) authorization in France in April 2021 for relapsed\/refractory multiple myeloma (RRMM). We conducted a real\u2010world registry\u2010based multicentre observational study in 11 French hospitals to evaluate ide\u2010cel outcomes. Data from 176 RRMM patients who underwent apheresis between June 2021 and November 2022 were collected from the French national DESCAR\u2010T registry. Of these, 159 patients (90%) received ide\u2010cel. Cytokine release syndrome occurred in 90% with 2% grade \u22653, and neurotoxicity occurred in 12% with 3% grade \u22653. Over the first 6\u2009months, the best overall response and \u2265complete response rates were 88% and 47% respectively. The median progression\u2010free survival (PFS) from the ide\u2010cel infusion was 12.5\u2009months, the median overall survival (OS) was 20.8\u2009months and the estimated OS rate at 12\u2009months was 73.3%. Patients with extra\u2010medullary disease (EMD) had impaired PFS (6.2\u2009months vs. 14.8\u2009months). On multivariable analysis, EMD and previous exposure to BCMA\u2010targeted immunoconjugate or T\u2010cell\u2010redirecting GPRC5D bispecific antibody were associated with inferior PFS. Our study supports ide\u2010cel's feasibility, safety and efficacy in real\u2010life settings, emphasizing the importance of screening for EMD and considering prior treatments to optimize patient selection.<\/jats:p>","DOI":"10.1111\/bjh.19505","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T08:35:51Z","timestamp":1715762151000},"page":"990-998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["French early nationwide idecabtagene vicleucel chimeric antigen receptor T\u2010cell therapy experience in patients with relapsed\/refractory multiple myeloma (FENIX): A real\u2010world IFM study from the DESCAR\u2010T registry"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1518-965X","authenticated-orcid":false,"given":"B.","family":"Ferment","sequence":"first","affiliation":[{"name":"Department of Immuno\u2010Hematology, H\u00f4pital Saint Louis APHP\/Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Inserm U976 HIPI, Team 5: Lymphocyte Development and Lymphoid Disorders H\u00f4pital Saint Louis  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Biostatistics Department, H\u00f4pital Saint Louis APHP\/Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Caillot","sequence":"additional","affiliation":[{"name":"Department of Hematology Institut de Canc\u00e9rologie de Bourgogne (ICB)  Dijon France"},{"name":"Department of Hematology Dijon University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Lafon","sequence":"additional","affiliation":[{"name":"Department of Hematology Institut de Canc\u00e9rologie de Bourgogne (ICB)  Dijon 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Oncology\u2010Haematology and Cellular Therapy Poitiers University Hospital  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Moya","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Haematology and Cellular Therapy Poitiers University Hospital  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Harel","sequence":"additional","affiliation":[{"name":"Department of Immuno\u2010Hematology, H\u00f4pital Saint Louis APHP\/Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Inserm U976 HIPI, Team 5: Lymphocyte Development and Lymphoid Disorders H\u00f4pital Saint Louis  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-8689","authenticated-orcid":false,"given":"A.","family":"Perrot","sequence":"additional","affiliation":[{"name":"Department of Hematology IUCT Oncopole\u2014Institut Universitaire du Cancer de 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[cited 2021 Jun 16]. Available from:https:\/\/www.myeloma.org\/resource\u2010library\/international\u2010myeloma\u2010working\u2010group\u2010imwg\u2010uniform\u2010response\u2010criteria\u2010multiple"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17338"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01365"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T13:51:27Z","timestamp":1729691487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,15]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/bjh.19505"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19505","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,15]]},"assertion":[{"value":"2024-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}