{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:36:27Z","timestamp":1792067787936,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008637","name":"Center for Strategic Scientific Initiatives, National Cancer Institute","doi-asserted-by":"publisher","award":["K12CA237806"],"award-info":[{"award-number":["K12CA237806"]}],"id":[{"id":"10.13039\/100008637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100024140","name":"ASH Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024140","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Most reports of risk factors (RF) for developing transplant\u2010associated thrombotic microangiopathy (TA\u2010TMA) and death are derived from paediatric and young adult cohorts, with minimal data on differences in RF and outcomes by age. In this secondary CIBMTR analysis, we used a previously prepared dataset that included all first allogenic haematopoietic cell transplantation (HCT) recipients with malignant or non\u2010malignant diseases between 2008 and 2016. The incidence of TA\u2010TMA 6\u2009months post HCT was similar in children and adults 2.1% and 2.0% respectively. Grade 2\u20134 acute graft\u2010versus\u2010host disease (aGVHD) was a significant adjusted RF for developing TA\u2010TMA in both children and adults. In adults, additional adjusted RFs for TA\u2010TMA included female sex and black race, and in children an unrelated donor. Compared to a calcineurin inhibitor and sirolimus, other forms of GVHD prophylaxis had an adjusted decreased risk of developing TA\u2010TMA in adults. Adjusted RF for death in those with TA\u2010TMA (<jats:italic>n<\/jats:italic>\u2009=\u2009652) included age \u226518\u2009years old, early onset of TA\u2010TMA diagnosis (&lt;100\u2009days post HCT), grade 3\u20134 aGVHD and a performance score of &lt;90 prior to HCT. In this cohort, the incidence of TA\u2010TMA was similar in children and adults, and TA\u2010TMA timing was a newly identified RF for death.<\/jats:p>","DOI":"10.1111\/bjh.19506","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T01:34:01Z","timestamp":1717119241000},"page":"243-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Age, <scp>GVHD<\/scp> prophylaxis, and timing matter in thrombotic microangiopathy after haematopoietic cell transplantation\u2014A\u00a0secondary <scp>CIBMTR<\/scp> analysis"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4565-6399","authenticated-orcid":false,"given":"Michelle L.","family":"Schoettler","sequence":"first","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University  Atlanta Georgia 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