{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:10:28Z","timestamp":1790727028795,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008658","name":"Deutsches Krebsforschungszentrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>The treatment of acute myeloid leukaemia (AML) has changed fundamentally in the last decade with many new targeted therapies entering clinics. Some of the most interesting agents under development are Menin inhibitors which interfere with the interaction of Menin with wild\u2010type (wt) KMT2A or a KMT2A\u2010fusion protein and thereby downregulate the leukaemic gene expression (MEIS1, PBX3, HOX) in <jats:italic>NPM1<\/jats:italic> mutant or <jats:italic>KMT2A<\/jats:italic>\u2010rearranged leukaemia. Other HOX and MEIS1 expressing leukaemias may also be sensitive to Menin inhibition. Following the encouraging results as monotherapy in refractory and relapsed AML, the combination of Menin inhibitors with chemotherapeutic agents and other targeted drugs is being investigated clinically.<\/jats:p>","DOI":"10.1111\/bjh.19508","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T01:29:45Z","timestamp":1715045385000},"page":"812-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The <scp>Menin story<\/scp> in acute myeloid leukaemia\u2014The road to success"],"prefix":"10.1111","volume":"205","author":[{"given":"Michael W. 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