{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:40:32Z","timestamp":1783525232415,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Bortezomib is regularly used as frontline therapy for systemic AL amyloidosis. We assess the efficacy of second\u2010line daratumumab\u2010bortezomib\u2010dexamethasone (DVD) in AL amyloidosis in bortezomib\u2010exposed patients. A total of 116 patients treated with second\u2010line DVD were identified from a prospective observational study of newly diagnosed AL amyloidosis (ALchemy). DVD was initiated in both the relapsed setting or where there was an inadequate response defined as very good partial response (VGPR) or VGPR with organ progression\/lack of organ improvement. A complete response (CR)\/VGPR to second\u2010line DVD was achieved in 81 (69.8%) patients. A CR\/VGPR was achieved in 67 (79.7%) in those who achieved a VGPR\/CR to first line versus 14\/32 (43.8%) in those who did not. Where DVD was initiated due to an inadequate response to first line (vs. at relapse), the median event\u2010free survival (EFS) was 18 vs. 34\u2009months (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). If a CR\/VGPR was achieved to DVD, the 2\u2010year EFS was still lower in those with prior inadequate response 54% vs. 66% (<jats:italic>p<\/jats:italic>\u2009=\u20090.062). DVD is an efficacious second\u2010line treatment in systemic AL amyloidosis in a bortezomib\u2010exposed population. However, the response to DVD is poorer in those with an inadequate response to first\u2010line bortezomib.<\/jats:p>","DOI":"10.1111\/bjh.19529","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T02:36:30Z","timestamp":1717641390000},"page":"138-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Response rates to second\u2010line treatment with daratumumab bortezomib dexamethasone (<scp>DVD<\/scp>) in relapsed\/refractory light chain amyloidosis (<scp>AL<\/scp>) after initial Bortezomib\u2010based regime"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-1013","authenticated-orcid":false,"given":"Joshua","family":"Bomsztyk","sequence":"first","affiliation":[{"name":"National Amyloidosis Centre University College London, Royal Free Campus  London 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