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Thirty\u2010two patients were transplanted from matched siblings or matched unrelated donors. In 22 patients, HSCT was performed due to insufficient molecular response or loss of response to first\u2010 or second\u2010generation tyrosine kinase inhibitor (TKI), with pretransplant <jats:italic>BCR::ABL1<\/jats:italic> transcripts ranging between 0.001% and 33%. The protocol included a <jats:italic>BCR::ABL1<\/jats:italic>\u2010guided intervention with TKI retreatment in the first year and donor lymphocyte infusions (DLI) in the second\u2010year post\u2010transplant. All patients engrafted. The 1\u2010year transplant\u2010related mortality was 3% (confidence interval [CI]: 0%\u20136%). After a median follow\u2010up of 6.3\u2009years, 5\u2010year overall survival and event\u2010free survival are 97% (CI: 93%\u2013100%) and 91% (CI: 79%\u2013100%) respectively. The current 5\u2010year leukaemia\u2010free survival with <jats:italic>BCR::ABL1<\/jats:italic> &lt;0.01% is 97% (CI: 88%\u2013100%) and the current TKI\u2010 and DLI\u2010free survival is 95% (CI: 85%\u2013100%). The incidence of chronic graft\u2010versus\u2010host disease (GvHD) was 32%, being severe in four patients (13%). At last follow\u2010up, 31 patients are GvHD\u2010free and have stopped immunosuppression. RIC HSCT following pretreatment with TKI is feasible and effective in children and adolescents with CP\u2010CML with an excellent disease\u2010free and TKI\u2010free survival.<\/jats:p>","DOI":"10.1111\/bjh.19535","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:33:51Z","timestamp":1716856431000},"page":"268-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Haematopoietic stem cell transplantation after reduced intensity conditioning in children and adolescents with chronic myeloid leukaemia: A prospective multicentre trial of the <scp>I\u2010BFM<\/scp> Study Group"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5107-5123","authenticated-orcid":false,"given":"Herbert","family":"Pichler","sequence":"first","affiliation":[{"name":"Department of Paediatric Haematology and Oncology St. Anna Children's Hospital  Vienna Austria"},{"name":"Department of Paediatrics and Adolescent Medicine Medical University of Vienna  Vienna Austria"},{"name":"Children's Cancer Research Institute Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Sedlacek","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology, University Hospital Motol Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Meisel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty Heinrich\u2010Heine\u2010University  Duesseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Beier","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-501X","authenticated-orcid":false,"given":"Maura","family":"Faraci","sequence":"additional","affiliation":[{"name":"Hematopoietic Stem Cell Transplantation Unit, Department of Hematology and Oncology IRCCS Institute G. 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