{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:29:37Z","timestamp":1784827777059,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Acute chest syndrome (ACS) is a leading cause of morbimortality in sickle cell disease (SCD). In this prospective observational study, we investigated sputum interleukin\u20106 (IL\u20106) level as an ACS severity marker during 30 ACS episodes in 26 SCD children. Sputum IL\u20106 levels measured within the first 72\u2009h of hospitalisation for ACS were significantly higher in patients with oxygen requirement \u22652\u2009L\/min, ventilation (invasive and\/or non\u2010invasive) length \u22655\u2009days, bilateral and\/or extensive opacities on chest X\u2010ray or erythrocytapheresis requirement. Sputum IL\u20106 could serve as an ACS severity marker to help identify patients requiring targeted anti\u2010inflammatory treatments such as tocilizumab.<\/jats:p>","DOI":"10.1111\/bjh.19561","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T01:59:49Z","timestamp":1716515989000},"page":"329-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sputum interleukin\u20106 level as a marker of severity during acute chest syndrome in children with sickle cell disease"],"prefix":"10.1111","volume":"205","author":[{"given":"Lara","family":"Mayrand","sequence":"first","affiliation":[{"name":"Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Imagine Institute, Inserm U1163 Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker\u2010Enfants Malades Hospital, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Elie","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Imagine Institute, Inserm U1163 Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker\u2010Enfants Malades Hospital, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Pinhas","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker\u2010Enfants Malades Hospital, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Laboratory of Excellence GR\u2010Ex  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Rignault\u2010Bricard","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Imagine Institute, Inserm U1163 Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Laboratory of Excellence GR\u2010Ex  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker\u2010Enfants Malades Hospital, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Laboratory of Excellence GR\u2010Ex  Paris 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Malades Hospital, AP\u2010HP Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Chhun","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Necker\u2010Enfants Malades Hospital, AP\u2010HP, INEM Institute, Inserm U1151 Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Trovati","family":"Maciel","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Imagine Institute, Inserm U1163 Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Laboratory of Excellence GR\u2010Ex  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical 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