{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T19:00:47Z","timestamp":1769281247075,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Therapeutic strategies for patients with newly diagnosed multiple myeloma (NDMM) have considerably improved during the last 10\u2009years. The IFM2014\u201003 trial proposed an all\u2010oral triplet induction\/consolidation regimen in transplant\u2010eligible NDMM patients, followed by lenalidomide maintenance. Induction consisted of three 21\u2010day\u2009cycles of ixazomib, lenalidomide and dexamethasone (IRd), before high\u2010dose Melphalan with transplant followed by eight 28\u2010day\u2009cycles of IRd consolidation before 13\u2009cycles of lenalidomide maintenance. Forty\u2010six patients were enrolled and received at least one dose of therapy, and 39 entered the maintenance phase. The primary end\u2010point was stringent complete response after consolidation, and was achieved in nine patients (20.9%, 90% CI 11.4\u201333.7; <jats:italic>p<\/jats:italic>\u2009=\u20090.998). Ten patients (24.4%) had an undetectable minimal residual disease. The overall response rate was 95.7%. The 3\u2010year progression\u2010free survival was 66.3%. No unexpected toxicities were recorded, and only eight patients suspended from any study drug. Of note, 21 (45.7%) patients reported peripheral neuropathy (PN) (grades 1\u20132 with no serious adverse events). IRd induction and consolidation with transplant before lenalidomide maintenance shows lower response rates compared to other triplet therapies. It could be an alternative for patients who require an all\u2010oral regimen and\/or with pre\u2010existent PN, especially if quadruplet regimens including anti\u2010CD38 antibody are not available.<\/jats:p>","DOI":"10.1111\/bjh.19570","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T01:14:47Z","timestamp":1717031687000},"page":"891-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Twice\u2010weekly induction with ixazomib\u2013lenalidomide\u2013dexamethasone (<scp>IRd<\/scp>) combination followed by extended <scp>IRd<\/scp> consolidation and lenalidomide maintenance in transplant\u2010eligible patients with newly diagnosed multiple myeloma: Results of the phase 2 study IFM2014\u201003"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-8689","authenticated-orcid":false,"given":"Aurore","family":"Perrot","sequence":"first","affiliation":[{"name":"Service H\u00e9matologie, Toulouse University Hospital  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murielle","family":"Roussel","sequence":"additional","affiliation":[{"name":"Service H\u00e9matologie, Limoges University Hospital  Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Lauwers\u2010Cances","sequence":"additional","affiliation":[{"name":"UMSR, Toulouse University  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-5161","authenticated-orcid":false,"given":"Cyrille","family":"Hulin","sequence":"additional","affiliation":[{"name":"Service Maladies du Sang, Bordeaux University Hospital  Bordeaux 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