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SCD treatment was abstracted from medical records. Linear regression models were fit to examine the relationship between log(AMH) and SCD, adjusting for age. The analysis was repeated to account for HU use (current, previous, never) and iron overload (ferritin \u22651000\u2009ng\/mL vs. &lt;1000\u2009ng\/mL). AMH estimates among women with SCD were lower than those among comparison women (2.23, 95% confidence interval [CI] 1.80\u20132.76 vs. 4.12, 95% CI 3.11\u20135.45, respectively). Women with SCD who were currently using HU had 63% lower (95% CI 43\u201376) AMH values than comparison women; those with SCD with prior or no HU use also had lower AMH estimates than comparison women, but the difference was less pronounced. There were no differences in predicted AMH values among women with SCD for those with and without iron overload. Women with SCD and low AMH may have a shorter reproductive window and may benefit from referral to a reproductive specialist.<\/jats:p>","DOI":"10.1111\/bjh.19582","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T08:49:17Z","timestamp":1717663757000},"page":"674-685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of sickle cell disease and its treatment on ovarian reserve in reproductive\u2010aged Black women"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1443-3651","authenticated-orcid":false,"given":"Lisa M.","family":"Shandley","sequence":"first","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics Emory University School of Medicine  Atlanta Georgia 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